| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
Proc Natl Acad Sci U S A, 2016;113(4):960-5.
Species: Human
Sample Type: Whole Cells
Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
Stem Cells, 2015;33(5):1670-81.
Species: Mouse
Sample Type: Whole Tissue
Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
Authors: Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, Mao C, Luberto C, Hannun Y, Obeid L
J Biol Chem, 2015;290(42):25356-73.
Species: Human
Sample Type: Whole Cells
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells
Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014;44(5):1745-55.
Species: Human
Sample Type: Whole Cells
Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
J Immunol, 2014;193(3):1258-67.
Species: Human
Sample Type: Whole Cells
Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade.
Authors: Liu, Yu-Kuo, Chen, Kuan-Hsi, Leu, Yann-Lii, Way, Tzong-De, Wang, Ling-Wei, Chen, Yu-Jen, Liu, Yu-Ming
Onco Targets Ther, 2014;8(0):99-109.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
Authors: You B, Shin H, Park W
Int J Oncol, 2014;44(1):301-8.
Species: Human
Sample Type: Whole Cells
Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
Int J Oncol, 2013;42(2):525-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin H, You B, Park W
Oncol Lett, 2013;6(6):1804-1810.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
Authors: Bauer G
Anticancer Res, 2013;33(9):3589-602.
Species: Human
Sample Type: Whole Cells
p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome.
Authors: Huang, Shengbin, Okamoto, Koichi, Yu, Chunrong, Sinicrope, Frank A
J Biol Chem, 2013;288(47):33654-66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
Elife, 2013;2(0):e00999.
Species: Drosophila
Sample Type: Whole Cells
Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
Cancer Cell Int, 2013;13(1):105.
Species: Human
Sample Type: Whole Cells
Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals.
Authors: Schoenmann Z, Assa-Kunik E, Tiomny S, Minis A, Haklai-Topper L, Arama E, Yaron A
J. Neurosci., 2010;30(18):6375-86.
Species: Mouse
Sample Type: Whole Cells
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010;115(24):5041-52.
Species: Human
Sample Type: Whole Cells
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Authors: Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V
Biochem. Pharmacol., 2009;77(11):1684-93.
Species: Human
Sample Type: Whole Cells
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
Authors: Park EJ, Zhao YZ, Kim YC, Sohn DH
Eur. J. Pharmacol., 2007;559(2):115-23.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
Authors: Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE
J. Neurosci., 2007;27(3):634-44.
Species: Chicken
Sample Type: Whole Cells
Apoptotic signaling induces hyperpermeability following hemorrhagic shock.
Authors: Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X
Am. J. Physiol. Heart Circ. Physiol., 2007;292(6):H3179-89.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Authors: Lee SC, Chan J, Clement MV, Pervaiz S
Proteomics, 2006;6(8):2386-94.
Species: Human
Sample Type: Cell Lysates
Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.
Authors: Lane D, Cote M, Grondin R, Couture MC, Piche A
Mol. Cancer Ther., 2006;5(3):509-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.
Authors: Conde de la Rosa L, Schoemaker MH, Vrenken TE, Buist-Homan M, Havinga R, Jansen PL, Moshage H
J. Hepatol., 2006;44(5):918-29.
Species: Human
Sample Type: Whole Cells
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45.
Species: Human
Sample Type: Whole Cells
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7.
Species: Human
Sample Type: Whole Cells
Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
Blood, 2004;104(9):2873-8.
Species: Human
Sample Type: Whole Cells
NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.
Authors: Taimen P, Kallajoki M
J. Cell. Sci., 2003;116(0):571-83.
Species: Human
Sample Type:
Apaf-1 is a mediator of E2F-1-induced apoptosis.
Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
J. Biol. Chem., 2002;277(42):39760-8.
Species: Human
Sample Type: Whole Cells
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
Authors: Yang D, He Y, Munoz-Planillo R, Liu Q, Nunez G
Immunity, 0;43(5):923-32.
Species: Mouse
Sample Type: Whole Tissue
Application: Other |
| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
