| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Induction of apoptosis by Armillaria mellea constituent armillarikin in human hepatocellular carcinoma
Onco Targets Ther, 2016;9(0):4773-83.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Authors: Jing Fang
Nat Med, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
Onco Targets Ther, 2016;9(0):4453-64.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells
Authors: Marie-Claude Gaudreau
Sci Rep, 2016;6(0):27379.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1
Mol Ther, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.
Authors: Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T
PLoS ONE, 2015;10(5):e0125779.
Species: Human
Sample Type: Whole Cells
Cold Atmospheric Plasma Induces a Predominantly Necrotic Cell Death via the Microenvironment.
Authors: Virard F, Cousty S, Cambus J, Valentin A, Kemoun P, Clement F
PLoS ONE, 2015;10(8):e0133120.
Species: Human
Sample Type: Whole Cells
Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis.
Authors: Braun F, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F
PLoS ONE, 2015;10(3):e0117994.
Species: Human
Sample Type: Whole Cells
IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth.
Authors: Sanz R, Ferraro G, Fournier A
J Biol Chem, 2015;290(7):4330-42.
Species: Rat
Sample Type: whole cells
Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis.
Authors: Lei, Y, Henderson, B R, Emmanuel, C, Harnett, P R, deFazio, A
Oncogene, 2015;34(4):485-95.
Species: Human
Sample Type: Whole Cells
Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL.
Authors: French R, Hayward O, Jones S, Yang W, Clarkson R
Mol Cancer, 2015;14(0):209.
Species: Human
Sample Type: Whole Cells
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells
Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
Authors: Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, Mao C, Luberto C, Hannun Y, Obeid L
J Biol Chem, 2015;290(42):25356-73.
Species: Human
Sample Type: Whole Cells
Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
Stem Cells, 2015;33(5):1670-81.
Species: Mouse
Sample Type: Whole Tissue
Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.
Authors: Tanaka N, Patel A, Wang J, Frederick M, Kalu N, Zhao M, Fitzgerald A, Xie T, Silver N, Caulin C, Zhou G, Skinner H, Johnson F, Myers J, Osman A
Clin Cancer Res, 2015;21(21):4831-44.
Species: Human
Sample Type: Whole Cells
A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.
Authors: Sanyal A, Chen A, Nakayasu E, Lazar C, Zbornik E, Worby C, Koller A, Mattoo S
J Biol Chem, 2015;290(13):8482-99.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells.
Authors: Kaushik, Neha, Lee, Su Jae, Choi, Tae Gyu, Baik, Ku Youn, Uhm, Han Sup, Kim, Chung Hy, Kaushik, Nagendra, Choi, Eun Ha
Sci Rep, 2015;5(0):8726.
Species: Human
Sample Type: Whole Cells
Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal.
Authors: Chung K, Park H, Jung S, Ha S, Yoo S, Woo H, Lee H, Kim S, Kim E, Moon C, Yu S
Stem Cells, 2015;33(10):3052-64.
Species: Rat
Sample Type: Whole Cells
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
Authors: You B, Shin H, Park W
Int J Oncol, 2014;44(1):301-8.
Species: Human
Sample Type: Whole Cells
Nlrx1 regulates neuronal cell death.
Authors: Imbeault E, Mahvelati T, Braun R, Gris P, Gris D
Mol Brain, 2014;7(0):90.
Species: Mouse
Sample Type: Whole Cells
The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis.
Authors: Mueller-Ortiz S, Morales J, Wetsel R
J Immunol, 2014;193(3):1278-89.
Species: Mouse
Sample Type: In Vivo
ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.
Authors: Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedstrom E, Issaeva N, Kel A, Arner E, Selivanova G
Cell Death Differ, 2014;21(4):612-23.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014;44(5):1745-55.
Species: Human
Sample Type: Whole Cells
Rose Bengal acetate photodynamic therapy (RBAc-PDT) induces exposure and release of Damage-Associated Molecular Patterns (DAMPs) in human HeLa cells.
Authors: Panzarini, Elisa, Inguscio, Valentin, Fimia, Gian Mar, Dini, Luciana
PLoS ONE, 2014;9(8):e105778.
Species: Human
Sample Type: Whole Cells
Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer.
Authors: Choi, Eun-Sun, Nam, Jeong-Se, Jung, Ji-Youn, Cho, Nam-Pyo, Cho, Sung-Dae
Sci Rep, 2014;4(0):7162.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
Int J Oncol, 2013;42(2):525-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
Cancer Cell Int, 2013;13(1):105.
Species: Human
Sample Type: Whole Cells
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
Authors: Zhang, Xiangnan, Yan, Haijing, Yuan, Yang, Gao, Jieqiong, Shen, Zhe, Cheng, Yun, Shen, Yao, Wang, Rong-Ron, Wang, Xiaofen, Hu, Wei-Wei, Wang, Guanghui, Chen, Zhong
Autophagy, 2013;9(9):1321-33.
Species: Rat
Sample Type: whole cells
Application: Inhibitor
Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke.
Authors: Li C, Liu Y, Chen Y, Yu D, Williams K, Liu M
Am J Pathol, 2013;182(5):1552-62.
Species: Human
Sample Type: Whole Cells
Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
Authors: McCloy R, Shelley E, Roberts C, Boslem E, Biden T, Nicholson R, Gee J, Sutherland R, Musgrove E, Burgess A, Butt A
Br J Cancer, 2013;109(12):3034-41.
Species: Human
Sample Type: whole cells
Application: cell culture
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin H, You B, Park W
Oncol Lett, 2013;6(6):1804-1810.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
Elife, 2013;2(0):e00999.
Species: Drosophila
Sample Type: Whole Cells
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Authors: Lamothe B, Lai Y, Xie M, Schneider M, Darnay B
Mol Cell Biol, 2013;33(3):582-95.
Species: Mouse
Sample Type: Whole Cells
Hexokinase 1 blocks apoptotic signals at the mitochondria.
Authors: Schindler A, Foley E
Cell Signal, 2013;25(12):2685-92.
Species: Human
Sample Type: whole cells
Application: Bioassay
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.
Cell Death Differ., 2012;19(9):1482-94.
Species: Human
Sample Type: Whole Cells
TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8.
Authors: Ikner A, Ashkenazi A
J. Biol. Chem., 2011;286(24):21546-54.
Species: Human
Sample Type: Whole Cells
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010;115(24):5041-52.
Species: Human
Sample Type: Whole Cells
Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP.
Authors: Park SJ, Kim MJ, Kim HB, Kang CD, Kim SH
Biochem. J., 2009;420(1):73-81.
Species: Human
Sample Type: Whole Cells
Effects of erythropoietin in skin wound healing are dose related.
Authors: Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B
FASEB J., 2009;23(9):3049-58.
Species: Mouse
Sample Type: In Vivo
Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway.
Authors: Park SJ, Kim MJ, Kim HB, Sohn HY, Bae JH, Kang CD, Kim SH
Biochem. Pharmacol., 2009;77(8):1328-36.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Authors: Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V
Biochem. Pharmacol., 2009;77(11):1684-93.
Species: Human
Sample Type: Whole Cells
Application: Flow
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
Stem Cells, 2008;26(7):1705-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Caspase inhibitor infusion protects an avian song control circuit from seasonal-like neurodegeneration.
Authors: Thompson CK, Brenowitz EA
J. Neurosci., 2008;28(28):7130-6.
Species: Avian- Gambels White Crowned Sparrows
Sample Type: In Vivo
Active caspase-1-mediated secretion of retinoic acid inducible gene-I.
Authors: Kim, Min-Jung, Yoo, Joo-Yeon
J Immunol, 2008;181(10):7324-31.
Species: Human
Sample Type: whole cells
Application: Bioassay
Theilers virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus.
Authors: Son KN, Becker RP, Kallio P, Lipton HL
J. Virol., 2008;82(9):4502-10.
Species: Mouse
Sample Type: Whole Cells
Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells.
Authors: Plachta N, Annaheim C, Bissiere S, Lin S, Ruegg M, Hoving S, Muller D, Poirier F, Bibel M, Barde YA
Nat. Neurosci., 2007;10(6):712-9.
Species: Mouse
Sample Type: Whole Cells
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
Authors: Park EJ, Zhao YZ, Kim YC, Sohn DH
Eur. J. Pharmacol., 2007;559(2):115-23.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
Authors: Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S
Blood, 2007;111(4):1951-61.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2.
Authors: Mongiat M, Ligresti G, Marastoni S, Lorenzon E, Doliana R, Colombatti A
Mol. Cell. Biol., 2007;27(20):7176-87.
Species: Human
Sample Type: Whole Cells
TLR3 can directly trigger apoptosis in human cancer cells.
Authors: Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T
J. Immunol., 2006;176(8):4894-901.
Species: Human
Sample Type: Whole Cells
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
Authors: Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M
J. Neurochem., 2006;98(1):45-56.
Species: Mouse
Sample Type: Whole Cells
Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006;56(2):243-52.
Species: Human
Sample Type: Whole Cells
Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
Mol. Cancer Ther., 2006;5(12):2977-90.
Species: Human
Sample Type: Whole Cells
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Authors: Lee SC, Chan J, Clement MV, Pervaiz S
Proteomics, 2006;6(8):2386-94.
Species: Human
Sample Type: Cell Lysates
Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
Cancer Lett., 2005;222(2):183-93.
Species: Human
Sample Type: Cell Lysates
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45.
Species: Human
Sample Type: Whole Cells
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7.
Species: Human
Sample Type: Whole Cells
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Authors: Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ
Eur. J. Immunol., 2002;32(5):1464-71.
Species: Human
Sample Type: Whole Cells
Apaf-1 is a mediator of E2F-1-induced apoptosis.
Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
J. Biol. Chem., 2002;277(42):39760-8.
Species: Human
Sample Type: Whole Cells
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