CAY10486
货号：
10006452-500mg 基本售价：
18480.0 元 规格：
500 mg
产品信息
概述| 货号 | 10006452-500mg |
| 描述 | Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.1,2 CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM.3 It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.3 |
| 别名 | 4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rudel, L.L.,Lee, R.G., and Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Current Opinion in Lipidology 12, 121-127 (2001).
2.Lee, R.G.,Willingham, M.C.,Davis, M.A., et al. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. Journal of Lipid Research 41, 1991-2001 (2000).
3.Lee, S.,Han, J.M.,Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorganic & Medicinal Chemistry Letters 14, 4677-4681 (2004).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 325.4 |
| 分子式 | C19H19NO4 |
| CAS号 | 615264-52-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
