bis(7)-Tacrine
货号：
10005836-100mg 基本售价：
12544.0 元 规格：
100 mg
产品信息
概述| 货号 | 10005836-100mg |
| 描述 | Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), and has been proposed as a clinical treatment for Alzheimer’s disease.1bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine.2bis(7)-Tacrine also protects against hydrogen peroxide induced apoptosis in rat pheochromocytoma cells.3 |
| 别名 | 1,7-N-heptylene-bis-9,9-amino-1,2,3,4-tetrahydro-acridine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Giacobini, E. Cholinesterase inhibitors for Alzheimer’s disease therapy: From tacrine to future applications. Neurochemistry International 32, 413-419 (1998).
2.Carlier, P.R.,Han, Y.F.,Chow, E.S.H., et al. Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorganic & Medicinal Chemistry 7, 351-357 (1999).
3.Hong, W.,Carlier, P.R.,Wing-Lok, H., et al. Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor. Acta Pharmacologica Sinica 20(3), 211-217 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 565.6 |
| 分子式 | C33H40N4 • 2HCl |
| CAS号 | 224445-12-9 |
| 稳定性 | ≥ 2 years |
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