| 货号 | 10006199-100ug |
| 描述 | Leukotriene D4-d5(LTD4-d5) contains five deuterium atoms at the 19, 19, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-mass spectrometry. LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2 It is the first cysteinyl leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.5,6 |
| 别名 | LTD4-d5; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Örning, L.,Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America 77, 2014-2017 (1980). 2.Hammarström, S.,Örning, L., and Bernström, K. Metabolism of leukotrienes. Molecular and Cellular Biochemistry 69, 7-16 (1985). 3.Hedqvist, P.,Dahlén, S.E.,Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiologica Scandinavica 110, 331-333 (1980). 4.Samuelsson, B.,Dahlén, S.E.,Lindgren, J.Å., et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237, 1171-1176 (1987). 5.Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochemical Pharmacology 35, 123-127 (1986). 6.Drazen, J.M.,Austen, K.F.,Lewis, R.A., et al. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America 77, 4354-4358 (1980). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d5) |
| 计算分子量 | 501.7 |
| 分子式 | C25H35D5N2O6S |
| CAS号 | 1240398-17-7 |
| 稳定性 | ≥ 1 year |
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