NESS 0327
货号：
10004184-5mg 基本售价：
11032.0 元 规格：
5 mg
产品信息
概述| 货号 | 10004184-5mg |
| 描述 | NESS 0327 is an extremely potent cannabinoid (CB) receptor antagonist with high selectivity for the CB1 receptor compared to the CB2 receptor with Ki values of 0.35 pM and 21 nM, respectively.1 It is a much more potent antagonist and more selective for the CB1 receptor compared to SR 141716A (rimonabant). At nM concentrations NESS 0327 competitively inhibits the binding of the synthetic CB agonist WIN 55,212-2 in isolated rat cerebella membranes and murine vas deferens.1,2 Unlike SR 141716A, NESS 0327 at higher doses does not act as a CB1 receptor inverse agonist and does not produce any physiological effects of its own.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ruiu, S.,Pinna, G.A.,Marchese, G., et al. Synthesis and characterization of NESS 0327: A novel putative antagonist of the CB1 cannabinoid receptor. Journal of Pharmacology and Experimental Therapeutics 306(1), 363-370 (2003).
2.Tambaro, S.,Mongeau, R.,Dessi, C., et al. Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. European Journal of Pharmacology 525, 150-153 (2005).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 489.8 |
| 分子式 | C24H23Cl3N4O |
| CAS号 | 494844-07-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
