Gestrinone
货号：
10006488-1000mg 基本售价：
9968.0 元 规格：
1 g
产品信息
概述| 货号 | 10006488-1000mg |
| 描述 | Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.1 It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.1 It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.2 Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.3 These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moghissi, K.S. Medical treatment of endometriosis. Clinical Obestetrics and Gynecology 45(3), 620-633 (1999).
2.Tamaya, T.,Fujimoto, J.,Watanabe, Y., et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstetricia et Gynecologica Scandinavica 65, 439-441 (1986).
3.Death, A.K.,mcGrath, K.C.Y.,Kazluskas, R., et al. Tetrahydrogestrinone is a potent androgen and progestin. Journal of Clinical Endocrinology and Metabolism 89(5, 2498-2500 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.4 |
| 分子式 | C21H24O2 |
| CAS号 | 16320-04-0 |
| 稳定性 | ≥ 2 years |
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