(S)-Flurbiprofen
货号：
10004207-1g 基本售价：
8624.0 元 规格：
1 g
产品信息
概述| 货号 | 10004207-1g |
| 描述 | Non-steroidal anti-inflammatory drugs (NSAIDs) are potent inhibitors of both COX-1 and COX-2 in humans, but are frequently supplied as racemates.1 Such is the case for the common 2-aryl propionic acid drug flurbiprofen, sold under the trade name Ansaid. In the 2-aryl propionic acid NSAID family, cyclooxygenase inhibition resides primarily in the (S)-enantiomer. In guinea pig whole blood, the IC50 value of (S)-flurbiprofen is about 0.5 µM for both COX-1 and COX-2.2 Only a small amount (<5%) of the (S)-enantiomer is converted to the (R)-enantiomer in rats and humans; therefore, the biological effects are specific to each enantiomer.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barnett, J.,Chow, J.,Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et Biophysica Acta 1209, 130-139 (1994).
2.Carabaza, A.,Cabre, F.,Rotllan, E., et al. Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs. Journal of Clinical Pharmacology 36, 505-512 (1996).
3.Brune, K.,Beck, W.S.,Geisslinger, G., et al. Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia 47, 257-261 (1991).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥99% |
| 计算分子量 | 244.3 |
| 分子式 | C15H13FO2 |
| CAS号 | 51543-39-6 |
| 稳定性 | ≥ 2 years |
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