| 货号 | 10006436-5g |
| 描述 | Free radicals are highly reactive, short-lived species. Spin traps react with radicals, forming stable adducts that can be further studied. DMPO is a commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals.1,2,3 This allows their characterization when used in association with electron spin resonance and immuno-spin trapping.4,5,6 DMPO is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be used in vitroandin vivo.7,8,9 |
| 别名 | 5,5-Dimethyl-1-Pyrroline-N-Oxide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chamulitrat, W.,Jordan, S.J., and Mason, R.P. Fatty acid radical formation in rats administered oxidized fatty acids: In vivo spin trapping investigation. Archives of Biochemistry and Biophysics 299, 361-367 (1992). 2.Dikalov, S.,Kirilyuk, I., and Grigorev, I. Spin trapping of O-,C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides. Biochemical and Biophysical Research Communications 218, 616-622 (1996). 3.Kalyanaraman, B.,Karoui, H.,Singh, R.J., et al. Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols - a high resolution ESR spin-trapping study at Q-band (35GHz). Analytical Biochemistry 241, 75-81 (1996). 4.Mason, R.P. Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping. Free Radical Biology & Medicine 36(10), 1214-1223 (2004). 5.Ramirez, D.C.,Mejiba, S.E.G., and Mason, R.P. Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: The role of copper- and carbonate radical anion-mediated oxidations. Free Radical Biology & Medicine (2004). 6.Detweiler, C.D.,Deterding, L.J.,Tomer, K.B., et al. Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Free Radical Biology & Medicine 33(3), 364-369 (2002). 7.Anzai, K.,Aikawa, T.,Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes. Archives of Biochemistry and Biophysics 415, 251-256 (2003). 8.Haseloff, R.F.,Mertsch, K.,Rohde, E., et al. Cytotoxicity of spin trapping compounds. FEBS Letters 418, 73-75 (1997). 9.Jiang, J.,Liu, K.J.,Jordan, S.J., et al. Detection of free radical metabolite formation using in Vivo EPR spectroscopy: Evidence of rat hemoglobin thiyl radical formation following administration of phenylhydrazine. Archives of Biochemistry and Biophysics 330, 266-270 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 113.2 |
| 分子式 | C6H11NO |
| CAS号 | 3317-61-1 |
| 稳定性 | ≥ 1 year |
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