PX-478
货号：
10005189-25mg 基本售价：
6622.0 元 规格：
25 mg
产品信息
概述| 货号 | 10005189-25mg |
| 描述 | PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes.1 It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1α level.1 PX-478 can also increase chemo- or radiosensitivity of tumors.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Welsh, S.,Williams, R.,Kirkpatrick, L., et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α. Molecular Cancer Therapeutics 3(3), 233-244 (2004).
2.Schwartz, D.L.,Bankson, J.A.,Lemos, R., Jr., et al. Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol. Cancer Ther. 9(7), 2057-2067 (2010).
3.Zhao, T.,Ren, H.,Jia, L., et al. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget 6(4), 2250-2262 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.1 |
| 分子式 | C13H18Cl2N2O3 • 2HCl |
| CAS号 | 685898-44-6 |
| 稳定性 | ≥ 2 years |
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