Leukotriene A4-d5 methyl ester
货号：
10006197-100ug 基本售价：
4788.0 元 规格：
100 ug
产品信息
概述| 货号 | 10006197-100ug |
| 描述 | Leukotriene A4-d5(LTA4-d5) methyl ester contains four deuterium atoms at the 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LTA4 methyl ester by GC- or LC-mass spectrometry. LTA4 is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities.1,2LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed. |
| 别名 | LTA4-d5 methyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shimizu, T.,Rådmark, O., and Samuelsson, B. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proceedings of the National Academy of Sciences of the United States of America 81, 689-693 (1984).
2.Samuelsson, B.,Dahlén, S.E.,Lindgren, J.Å., et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237, 1171-1176 (1987).
3.Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4. The Journal of Biological Chemisty 263, 174-181 (1988).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d5) |
| 计算分子量 | 337.5 |
| 分子式 | C21H27D5O3 |
| 稳定性 | ≥ 1 year |
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