Prostaglandin D Synthase (lipocalin-type; human recombinant)
货号：
10006788-250ug 基本售价：
3710.0 元 规格：
250 ug
产品信息
概述| 货号 | 10006788-250ug |
| 描述 | Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme and the hematopoietic enzyme.1,2,3 L-PGDS is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as β-trace, which is a major protein in human cerebrospinal fluid.1 Cayman’s human recombinant L-PGDS is an active, highly-purified GST-fusion protein isolated from an E. coli expression system. Cysteines 89, 138, and 186 have been changed to alanines to prevent protein misfolding without affecting enzyme activity. The enzyme is ideally suited for a variety of biochemical experiments including mechanistic studies and development of selective enzyme inhibitors. |
| 别名 | Lipocalin-PGDS;L-PGDS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Urade, Y.,Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. Journal of Lipid Mediators and Cell Signalling 12, 257-273 (1995).
2.Urade, Y., and Hayaishi, O. Prostaglandin D synthase: Structure and function. Vitamins and Hormones 58, 89-120 (2000).
3.Urade, Y., and Eguchi, N. Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins & Other Lipid Mediators 68-69, 375-382 (2002).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥85% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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