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货号： bs-0214R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0214R-Cy5.5
- 英文名称
- Anti-ICAD/Cy5.5
- 中文名称
- Cy5.5标记的Caspase激活的脱氧核糖核酸酶抑制剂抗体
- 别 名
- DFF-45 Beta; ICAD; ICAD L; ICAD S; Caspase activated deoxyribonuclease inhibitor short form; DFF 1; DFF 45; DFF-45; DFF alpha; DFF1; DFF35; DFF45; DFFA; Dffa DNA fragmentation factor, alpha subunit; DNA fragmentation factor 45 kDa subunit; DNA Fragmentation Factor Alpha Subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45 kD, alpha subunit; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1; A330085O09Rik; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; Inhibitor of CAD; DFFA_HUMAN; Inhibitor of CAD; Inhibitor of Caspase Activated DNase; MGC143066; OTTHUMP00000001903; OTTHUMP00000001904; RP23 121D17.3;Inhibitor of Caspase Activated DNase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 细胞凋亡 新陈代谢 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ICAD
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Caspase-activated deoxyribonuclease(CAD) also designated DNA fragmentation factor 45 kDa subunit (DFF-45)and Caspase-activated DNase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. ICAD (DNA fragmentation factor alpha subunit) (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) is inhibitor of the caspase-activated DNase (DFF44).
Function:
Inhibitor of the caspase-activated DNase (DFF40).
Subunit:
Heterodimer of DFFA and DFFB.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
Similarity:
Contains 1 CIDE-N domain.
Database links:Entrez Gene: 1676Human
Omim: 601882Human
SwissProt: O00273Human
Unigene: 484782Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ICAD 是在细胞凋亡期诱导DNA分裂和染色体固缩的一种核酶，降解裸露的DNA 并诱导形态学变化。