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货号： bs-1031R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1031R-Cy5.5
- 英文名称
- Anti-IFITM1/Cy5.5
- 中文名称
- Cy5.5标记的干扰素诱导跨膜蛋白1抗体
- 别 名
- CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu 13 antigen; Leu-13 antigen; LEU13; IFM1_HUMAN; Dispanin subfamily A member 2a; DSPA2a.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 11.7kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IFITM1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker.
Function:
IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
Subunit:
Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Post-translational modifications:
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
Similarity:
Belongs to the CD225 family.
Database links:Entrez Gene: 8519Human
Entrez Gene: 68713Mouse
Entrez Gene: 293618Rat
Omim: 604456Human
SwissProt: P13164Human
SwissProt: Q9D103Mouse
Unigene: 458414Human
Unigene: 175661Mouse
Unigene: 22087Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IFITM1蛋白是蛋白复合物的组分之一,主要功能是参与同型粘附和抗增殖信号的转导,与细胞增殖、肿瘤分化、抗病毒、免疫监视等有关。IFITM-1主要用于消化系统肿瘤方面的研究，有学者认为：干扰素诱导跨膜蛋白1与干扰素结合，可以抑制肿瘤细胞的分化和增值。