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货号： bs-8844R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-8844R
- 英文名称
- SMAD8
- 中文名称
- SMAD8蛋白抗体
- 别 名
- AI528653 ; BSP 1 ; BSP1 ; DKFZp781C1895 ; DKFZp781O1323 ; Dwarfin A ; Dwf A ; DwfA ; Dwfc ; hSMAD1 ; hSmad5 ; JV 41 ; JV4 1 ; JV41 ; JV5 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 1 ; MAD (mothers against decapentaplegic, Drosophila) homolog 9 ; MAD homolog 1 ; MAD homolog 9 ; MAD homolog1 (mothers against decapentaplegic, Drosophila) ; Mad related protein 1 ; MAD, mothers against decapentaplegic homolog 9 ; MADH 1 ; Madh1 ; MADH5 ; MADH6 ; MADH9 ; Madr 1 ; MADR1 ; Mlp1 ; Mothers against decapentaplegic, drosophila, homolog of, 9 ; Mothers against DPP homolog 1 ; Mothers against DPP homolog 9 ; MusMLP ; OTTHUMP00000178565 ; OTTMUSP00000022970 ; OTTMUSP00000022971 ; OTTMUSP00000022972 ; OTTMUSP0000002324 ; OTTMUSP00000023428 ; Sma and Mad related protein 1 ; Sma- and Mad-related protein 1 ; SMAD ; SMAD family member 5 ; SMAD mothers against DPP homolog 1 Drosophila ; SMAD8 ; SMAD8A ; SMAD8B ; Spinal muscular atrophy distal with upper limb predominance ; TGF beta signaling protein 1 ; Transforming growth factor beta signaling protein 1 ; Transforming growth factor-beta signaling protein 1.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 生长因子和激素 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Zebrafish,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SMAD8:351-450/467
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Function:
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway
Subcellular Location:
Cytoplasmic and Nuclear.
Similarity:
Belongs to the sphingomyelin synthase family.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q96LT4
Gene ID:
142891
Database links:Entrez Gene: 4086Human
Entrez Gene: 4090Human
Entrez Gene: 4093Human
Entrez Gene: 17125Mouse
Entrez Gene: 17129Mouse
Entrez Gene: 55994Mouse
Entrez Gene: 25671Rat
Entrez Gene: 59328Rat
Entrez Gene: 85435Rat
Omim: 601595Human
Omim: 603110Human
Omim: 603295Human
SwissProt: O15198Human
SwissProt: Q15797Human
SwissProt: Q99717Human
SwissProt: P70340Mouse
SwissProt: P97454Mouse
SwissProt: Q9JIW5Mouse
SwissProt: O54835Rat
SwissProt: P97588Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.