| 货号 | RDC2028 |
| 别名 | GLC1A; GLC1Amyocilin; GPOA; JOAG; JOAG1; MYOC; Myocilin; myocilin, trabecular meshwork inducible glucocorticoid response; TIGR; TIGRmutated trabecular meshwork-induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4653 (Human) |
| 背景 | Myocilin is a variably glycosylated, 65 kDa, secreted polypeptide that belongs to the family of olfactomedin-related proteins. Human Myocilin is synthesized as a 490 amino acid (aa) precursor that contains an 18 aa signal sequence, an 84 aa N-terminus containing a coiled-coil domain, a 53 aa alpha-helical leucine zipper and a 335 aa C-terminus that contains a 260 aa OLF-domain. An alternate start site generates a 504 aa mature protein without a signal sequence. Myocilin forms nondisulfide-linked dimers and multimers. The human 32 kDa OLF-domain shares 87% aa sequence identity with the OLF-domain in bovine, rat and mouse. Mutations in the OLF-domain of this protein can result in glaucoma. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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