Human FCRN (NP_004098) VersaClone cDNA (10 UG)
货号：
RDC1817 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1817 |
| 别名 | alpha-chain; Fc fragment of IgG, receptor, transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRNimmunoglobulin receptor, intestinal, heavy chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig |
全称 | Neonatal Fc Receptor |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2217 (Human); 14132 (Mouse); 29558 (Rat) |
| 背景 | FcRN (the neonatal Fc receptor) is a transmembrane MHC class I-like glycoprotein that is widely expressed on endothelial and epithelial cells. Mouse FcRN binds with high affinity to IgG from mouse, human, rat, rabbit, guinea pig, bovine, and sheep, while human FcRN binds IgG with significantly lower affinity and is much more restricted in terms of species recognition. It additionally binds to Albumin and beta 2-Microglobulin. FcRN is involved in recycling endocytosed IgG and Albumin, the bidirectional transport of IgG across epithelial and endothelial barriers, and intestinal uptake of maternal antibodies by the fetus. In the kidney, FcRN recycles Albumin to the serum but removes IgG from the glomular basement membrane and promotes its excretion into the urine. FcRN can also enhance IgG-mediated phagocytosis and antigen presentation by neutrophils and myeloid antigen presenting cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | |
