概述| 货号 | RDC1262 |
| 别名 | CD; CD152 antigen; CD152; CD152IDDM12; CD28; celiac disease 3; CELIAC3; CTLA-4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 |
全称 | Cytotoxic T-lymphocyte-associated Molecule 4 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 1493 (Human); 12477 (Mouse); 102115124 (Cynomolgus Monkey) |
| 背景 | CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Activation
- Co-stimulatory and Co-inhibitory Molecules
- CTLA-4: Hiding in Plain Sight
- Dendritic Cell Co-stimulatory Molecules
- Human CD Marker Products
- ITIM/ITAM Immunoreceptors and Related Molecules
- Mini-review: B7 & CD28 Superfamilies
- Mini-review: B7 & CD28/CTLA-4 Receptor Families
- Regulatory T Cells (Tregs)
- Technical Notes: B7 Family Research Tools
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