| 货号 | RDC0481 |
| 别名 | MGC120477; MNAT; monoamine neurotransmitter transporter; Monoamine transporter; SLC18A2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 member 2; SVAT; SVMT; SVMTMGC120478; synaptic vesicular amine transporter; VAT2; VAT2MGC26538; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; Vesicular amine transporter 2; VMAT2 | 全称 | Vesicular Monoamine Transporter 2/Solute Carrier Family 18, Member 2 |
| 反应种属 | Human |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6571 (Human); 214084 (Mouse); 25549 (Rat) |
| 背景 | The vesicular monoamine transporter 2 (VMAT2; also known as VAT2 and SCL18A) is a 55 - 75 kDa member of the vesicular transporter family, a major facilitator superfamily. VMAT2 is a 12 transmembrane (TM) glycoprotein that is found in the membrane of brain neurosecretory vesicles. It transports monoamines (dopamine, serotonin, and particularly histamine) from the cytosol into secretion vesicles by exchanging two H+ ions for one molecule of amine. Human VMAT2 is 514 amino acids (aa) in length. It contains a 20 aa and 52 aa N- and C-terminal cytoplasmic domain, plus an extended 88 aa luminal loop between aa 42 - 129. There is one luminal, intrachain disulfide bond that contributes to amine transport (C126 - C333). In addition, residues in TM domains 5 - 8 (aa 220 - 352) and 9 - 12 (aa 358 - 462) also contribute to high affinity ligand interaction. VMAT2 is constitutively phosphorylated by CKII on S511 and S513. Within the cytoplasmic C-terminus, human VMAT2 is 94% aa identical to rat VMAT2. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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