Human IL-6 R alpha (NP 000556) VersaClone cDNA (10 UG)
货号：
RDC1155 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1155 |
| 别名 | CD126; IL6R |
全称 | Interleukin 6 Receptor alpha | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3570 (Human); 16194 (Mouse) |
| 背景 | IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Activation
- Cancer Stem Cell Markers
- Cytokines and Receptors in Allergy and Asthma
- Cytokines and Receptors in Angiogenesis
- Cytokines and Receptors in Tfh Cell Differentiation and Function
- Diabetes
- Human CD Marker Products
- ICC / IHC Images: IL-6 R alpha
- IL-6 Family
- Mini-review: Interleukin 6
- Monocyte Markers
- Multiple Sclerosis and Myelin Related Molecules
- Myeloid-derived Suppressor Cells (MDSC)
- Neuroinflammation
- Obesity
- Receptors in the Jak/STAT Pathway
- T Cell Cytokine Signaling
- Th17 Cells
- Th22 Cells
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