概述| 货号 | RDC1030 |
| 别名 | BB2; CD54 antigen; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor; P3.58 |
全称 | Intercellular Adhesion Molecule 1 | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3383 (Human); 15894 (Mouse); 25464 (Rat) |
| 背景 | ICAM-1 (intercellular adhesion molecule-1), also known as CD54, is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin, Fibrinogen, Hyaluronan, rhinoviruses, and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease, type 2 diabetes, organ transplant dysfunction, oxidant stress, increased abdominal fat mass, hypertension, liver disease, certain malignancies, and cerebral malaria. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Adhesion Molecules
- Adhesive Interactions in Allergy and Asthma
- Adipose-derived Stem Cell Markers
- B Cell Chemotaxis, Migration, and Adhesion
- Dendritic Cell Adhesion and Migration
- Endothelial Cell Markers
- Endothelial Cell Markers and Adhesion Molecules in Angiogenesis
- Human CD Marker Products
- ICC / IHC Images: ICAM-1/CD54
- Immunoglobulin Superfamily CAMs
- Mesenchymal Stem Cell Markers
- Mini-review: Cytolytic Granule-mediated Apoptosis
- Monocyte Markers
- Myeloid-derived Suppressor Cells (MDSC)
- Neuroinflammation
- Plasma ICAM-1 is Correlated with Increased Risk of Cardiovascular Disease
- Platelets
- Regulatory T Cells (Tregs)
- T Cell Migration/Adhesion
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