Human Frizzled-2 VersaClone cDNA (10 UG)
货号:
RDC0426 基本售价:
2825.6 元 规格:
10 ug
产品信息
概述货号 | RDC0426 |
别名 | frizzled (Drosophila) homolog 2; frizzled homolog 2 (Drosophila); frizzled-2; Fz2; fz-2; FZD2; fzE2; hFz2 |
反应种属 | Human |
性能供应商 | R&D Systems |
Entrez Gene IDs | 2535 (Human); 57265 (Mouse) |
背景 | This group of G protein-coupled receptors consists of 10 structurally-related, seven transmembrane proteins with a divergent N-terminal signal peptide and a variable-length C-terminal tail. The Frizzled family proteins contain a highly conserved cysteine-rich domain and a variable length linker region. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Planar Cell Polarity and Wnt/Ca2+Pathways). Wnt/Frizzled signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning, and control of cell proliferation. Activation of a given Wnt/Frizzled signaling cascade is dependent on the Wnt ligand and the cell context. Frizzled proteins also form co-receptor complexes with LRP, ROR, and Ryk molecules. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
参考文献 | - Frizzled Receptors
- Mini-review: Wnt Receptors & Pathways
- Ryk: A Wnt Co-receptor at the Intersection of Frizzled & Dishevelled
- Skin Stem Cell Markers
- Technical Notes: Wnt Inhibitor Activity
- Wnt Family
- Wnt Receptors
- Wnt Signaling and sFRPs
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