Cynomolgus Monkey PD-L2/B7-DC (XP 005581839) VersaClone cDNA (10 UG)
货号：
RDC1291 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1291 |
| 别名 | B7-DC; bA574F11.2; Btdc; Butyrophilin B7-DC; Butyrophilin-like Protein; CD273 antigen; CD273; CD273PD-1 ligand 2; MGC142240; PD-1-ligand 2; PDCD1L2MGC142238; PDCD1LG2; PDL2B7DC; PD-L2PDCD1 ligand 2; programmed cell death 1 ligand 2; Programmed death ligand 2 |
全称 | Programmed Death-1 Ligand-2 | | 反应种属 | Cynomolgus Monkey |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 80380 (Human); 58205 (Mouse); 102146227 (Cynomolgus Monkey) |
| 背景 | PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B7/CD28 Family
- Co-stimulatory and Co-inhibitory Molecules
- Co-stimulatory Molecules Associated with Tfh Cells
- Dendritic Cell Co-stimulatory Molecules
- Human CD Marker Products
- ICC / IHC Images: PD-L2/B7-DC
- Mini-review: B7 & CD28 Superfamilies
- Mini-review: B7 & CD28/CTLA-4 Receptor Families
- Mini-review: Immune Tolerance
- Regulatory T Cells (Tregs)
- Technical Notes: B7 Family Research Tools
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