Cynomolgus Monkey B7-H1/PD-L1 (XP 005581836) VersaClone cDNA (10 UG)
货号：
RDC1288 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1288 |
| 别名 | B7-H; B7-H1; B7H1PDCD1L1; CD274 antigenMGC142294; CD274 molecule; CD274; PDCD1L1; PDCD1LG1; PDCD1LG1MGC142296; PD-L1; PD-L1B7 homolog 1; PDL1PDCD1 ligand 1; programmed cell death 1 ligand 1; Programmed death ligand 1 |
全称 | B7 Homolog 1 | | 反应种属 | Cynomolgus Monkey |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 29126 (Human); 60533 (Mouse); 102145573 (Cynomolgus Monkey) |
| 背景 | B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. B7-H1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. B7-H1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, B7-H1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Control of Immune Responses via CD28 and CTLA-4
- Co-stimulatory and Co-inhibitory Molecules
- Co-stimulatory Molecules Associated with Tfh Cells
- Epithelial Cell Markers and Intracellular Molecules
- Human CD Marker Products
- Mini-review: B7 & CD28 Superfamilies
- Mini-review: B7 & CD28/CTLA-4 Receptor Families
- Mini-review: Dendritic Cell Maturation
- Mini-review: Immune Tolerance
- Mini-review: Th1/Th2
- Myeloid-derived Suppressor Cells (MDSC)
- Regulatory T Cells (Tregs)
- Surface Ectodermal Cells
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