概述| 货号 | RDC1568 |
| 别名 | VSIG9; VSTM3; WUCAM |
全称 | T Cell Immunoreceptor with Ig and ITIM Domains | | 反应种属 | Cynomolgus Monkey |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 201633 (Human); 100043314 (Mouse); 363784 (Rat); 102121588 (Cynomolgus Monkey) |
| 背景 | TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3, Vsig9, and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 on dendritic cells (DC) and endothelium. Binding of TIGIT by DC induces IL-10 release and inhibits IL-12 production. Ligation of TIGIT on T cells downregulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. CD155 and Nectin-2 also interact with DNAM-1/CD226 and CD96/Tactile, and TIGIT binding to CD155 can antagonize the effects of DNAM-1. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses, while mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Co-stimulatory and Co-inhibitory Molecules
- Dendritic Cell Co-stimulatory Molecules
- IL-10/Interferon Family
- Infectious Diseases
- ITIM/ITAM Immunoreceptors and Related Molecules
- Nectin and Nectin-like Binding Receptors and Ligands
- Regulatory T Cells (Tregs)
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