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货号： bs-19985R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19985R
- 英文名称
- PRDM14
- 中文名称
- PRDM锌指转录因子PRDM14抗体
- 别 名
- MGC59730; PFM 11; PFM11; PFM11; PR domain containing 14; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing protein 14; PRD14_HUMAN; PRDM 14; PRDM14.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 转录调节因子 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 64kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PRDM14:361-460/571
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
Function:
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Similarity:
Contains 6 C2H2-type zinc fingers.
Contains 1 SET domain.
SWISS:
Q9GZV8
Gene ID:
63978
Database links:Entrez Gene: 100140032Cow
Entrez Gene: 486988Dog
Entrez Gene: 63978Human
Entrez Gene: 383491Mouse
Entrez Gene: 100519142Pig
Entrez Gene: 297769Rat
Omim: 611781Human
SwissProt: Q9GZV8Human
SwissProt: E9Q3T6Mouse
Unigene: 287532Human
Unigene: 309380Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.