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货号： bs-19926R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19926R
- 英文名称
- SMARCD2
- 中文名称
- SWI/SNF相关基质关联肌动蛋白依赖染色质调控因子亚家族D2抗体
- 别 名
- 60 kDa BRG 1/Brm associated factor subunit B; 60 kDa BRG1/Brm associated factor subunit B; BAF60B; BRG1 associated factor 60B; Chromatin remodeling complex BAF60B subunit; CRACD 2; CRACD2; Mammalian chromatin remodeling complex BRG1 associated factor 60B; PRO2451; Rsc6p; SMARCD 2; SWI/SNF complex 60 kDa subunit B; SWI/SNF related matrix associated actin dependent regulator of chromatin d2; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 2; Swp73 like protein.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 染色质和核信号 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SMARCD2:301-400/531
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
Subunit:
Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May interact with SMARCA4, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. Interacts with UNKL.
Subcellular Location:
Nuclear
Tissue Specificity:
Isoform 2 is expressed in the pancreas.
Post-translational modifications:
Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.
Similarity:
Belongs to the SMARCD family.
Contains 1 SWIB domain.
SWISS:
Q92925
Gene ID:
6603
Database links:Entrez Gene: 6603Human
Entrez Gene: 83796Mouse
Entrez Gene: 83833Rat
Omim: 601736Human
SwissProt: Q92925Human
SwissProt: Q99JR8Mouse
SwissProt: O54772Rat
Unigene: 250581Human
Unigene: 21772Mouse
Unigene: 3053Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.