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货号： bs-19853R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19853R
- 英文名称
- RGS12
- 中文名称
- G蛋白信号转导调节因子12抗体
- 别 名
- DKFZp761K1617; Regulator of G protein signalling 12.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 表观遗传学 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 156kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RGS12:601-700/1447
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a member of the regulator of G protein signaling (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.
Subunit:
Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.
Subcellular Location:
Nuclear
Tissue Specificity:
Isoform 3 is brain specific.
Similarity:
Contains 1 GoLoco domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PID domain.
Contains 2 RBD (Ras-binding) domains.
Contains 1 RGS domain.
SWISS:
O14924
Gene ID:
6002
Database links:Entrez Gene: 6002Human
Entrez Gene: 71729Mouse
Entrez Gene: 54292Rat
Omim: 602512Human
SwissProt: O14924Human
SwissProt: Q8CGE9Mouse
SwissProt: O08774Rat
Unigene: 196208Mouse
Unigene: 9796Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.