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货号： bs-19851R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-19851R
- 英文名称
- RGS1
- 中文名称
- G蛋白信号转导调节因子1抗体
- 别 名
- 1R20; B cell activation protein BL34; B-cell activation protein BL34; BL34; Early response protein 1R20; IER 1; IER1; Immediate early response 1 B cell specific; immediate-early response 1, B-cell specific; IR20; Regulator of G protein signalling 1; Regulator of G-protein signaling 1; RGS 1; RGS1; RGS1_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 信号转导 淋巴细胞 b-淋巴细胞 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RGS1:111-209/209
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
Tissue Specificity:
B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
Post-translational modifications:
Could be phosphorylated. Might be functionally regulated by protein kinase(s).
Similarity:
Contains 1 RGS domain.
SWISS:
Q08116
Gene ID:
5996
Database links:Entrez Gene: 100034151Horse
Entrez Gene: 5996Human
Entrez Gene: 50778Mouse
Entrez Gene: 54289Rat
Omim: 600323Human
SwissProt: Q6RG78Horse
SwissProt: Q08116Human
SwissProt: Q9JL25Mouse
SwissProt: P97844Rat
Unigene: 75256Human
Unigene: 103701Mouse
Unigene: 14787Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.