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货号： bs-4270R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4270R-Cy5.5
- 英文名称
- Anti-CDKN2C/p18 INK4c/Cy5.5
- 中文名称
- Cy5.5标记的细胞周期蛋白依赖性激酶抑制剂2C抗体
- 别 名
- CDK6 inhibitor p18; CDKN 2C; CDKN 6; CDKN2C; CDKN6; CDN2C_HUMAN; Cyclin dependent inhibitor; Cyclin dependent kinase 4 inhibitor C; Cyclin dependent kinase 6 inhibitor; Cyclin dependent kinase 6 inhibitor p18; Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4); Cyclin dependent kinase inhibitor 2C; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; INK4C; OTTHUMP00000046546; p18; p18 inhibits CDK4; p18 INK4c; p18 INK6; p18-INK4c; p18-INK6.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 18kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CDKN2C
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
p18 INK4c is a specific inhibitor of cdk4 / cdk6 (it interacts strongly with CDK6 and weakly with CDK4), and is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S phase. Highest expression levels are found in skeletal muscle, but it is also found in the pancreas and heart.
Function:
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Subunit:
Heterodimer of p18 with CDK6.
Tissue Specificity:
Highest levels found in skeletal muscle. Also found in pancreas and heart.
Similarity:
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats.
Database links:Entrez Gene: 469319Chimpanzee
Entrez Gene: 505691Cow
Entrez Gene: 475359Dog
Entrez Gene: 101125732Gorilla
Entrez Gene: 1031Human
Entrez Gene: 12580Mouse
Entrez Gene: 29658Rat
Entrez Gene: 711877 Rhesus monkey
Omim: 603369Human
SwissProt: P42773Human
SwissProt: Q60772Mouse
Unigene: 525324Human
Unigene: 728783Human
Unigene: 1912Mouse
Unigene: 63865Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.