Human Calpain 1 Inhibitor Screening Kit (Fluorometric)
货号：
K244-100 基本售价：
7762.5 元 规格：
100assays
产品信息
概述| 货号 | K244-100 |
| 描述 | Calpain 1 is calcium-dependent, non-lysosomal cysteine protease with low calcium requirement. It is expressed ubiquitously and in the brain, mainly localized to the cell body and dendrites of neurons and to a lesser extent in axons and glial cells. Hyperactivation of calpains is implicated in a number of pathologies associated with altered calcium homeostasis such as Alzheimer’s disease as well as secondary degeneration resulting from acute cellular stress following cerebral (neuronal) ischemia, traumatic brain injury and spinal cord injury. BioVision’s human calpain 1 inhibitor screening kit is based on the detection of cleavage of calpain substrate Ac-LLY-AFC. Ac-LLY-AFC possess very weak fluorescence; upon cleavage of the substrate by calpain 1, free AFC can be quantified fluorometrically (Ex/Em = 400/505 nm). In the presence of potent Calpain 1 inhibitor, the hydrolyzation of substrate will be impeded. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Calpain 1 inhibitors. Inhibitor control (Calpain inhibitor 1, ALLN) is included to compare the efficacy of test inhibitors. |
| 同种亚型 | Rabbit IgG |
| 来源宿主 | Rabbit |
性能| 供应商 | Biovision |
| 检测类型 | Fluorescence (Ex/Em= 400/505 nm)• Species reactivity- Mammalian • Applications- The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Calpain 1 inhibitors. Inhibitor control (Calpain inhibi |
| 样本类型以及上样量 | N/A |
| 产品特色 | • Simple procedure• Fast and convenient• The assay is sensitive, stable and high-throughput adaptable |
| 试剂盒组分 | • Calpain 1 Assay Buffer• Calpain 1 Substrate• Calpain 1 Enzyme• Inhibitor Control (Calpain Inhibitor 1, ALLN) [1 μM] |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
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