HMG-CoA Reductase Activity/Inhibitor Screening Kit (Colorimetric)
货号：
K588-100 基本售价：
7399.5 元 规格：
100assays
产品信息
概述| 货号 | K588-100 |
| 描述 | HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. The enzyme is target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol. BioVision’s HMG-CoA Reductase Activity Assay Kit measures utilization of NADPH, which can be measured by the decrease of absorbance (OD 340 nm). The kit is suitable for measuring activity of purified enzyme and screening inhibitors/activators of HMG-CoA reductase. The limit of detection is below 0.05 mU. |
| 同种亚型 | Rabbit IgG |
| 来源宿主 | Rabbit |
性能| 供应商 | Biovision |
| 检测类型 | Absorbance (OD 340 nm)• Applications - Measurement of HMG-CoA reductase activity- Screening/studying/characterizing HMG-CoA reductase inhibitors/activators |
| 样本类型以及上样量 | • Partially purified and recombinant enzyme |
| 产品特色 | • Simple, rapid & convenient• Limit of detection: below 0.05 mU• Includes inhibitor (Atorvastatin) |
| 试剂盒组分 | • HMG-CoA Reductase Assay Buffer • HMG-CoA Reductase • HMG-CoA• NADPH• Inhibitor (Atorvastatin, 10 mM) |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
