MMP-1 Inhibitor Screening Kit (Fluorometric)
货号：
K794-100 基本售价：
6189.5 元 规格：
100assays
产品信息
概述| 货号 | K794-100 |
| 描述 | The Matrix metalloproteinase-1 (MMP-1, Interstitial collagenase, fibroblast collagenase) is a member of a multigene family of calcium-dependent, zinc-containing endoproteinases, the matrix metalloproteinases (MMPs). The MMPs are responsible for the degradation of the extracellular matrix (ECM) including collagens, elastins, gelatin, matrix glycoproteins and proteoglycan during normal development and disease processes. MMPs are regulated by hormones, growth factors and cytokines. MMP-1 belongs to the subclass, the collagenases, and along with MMP-8, and MMP-13 are the only members of the MMP family that are capable of degrading the types I, II and III interstitial collagens with high efficiency. These collagens are primarily found in bone, cartilage and skin. In BioVision’s MMP-1 Inhibitor Screening Kit, MMP-1 hydrolyzes a specific FRET substrate to release a quenched fluorescent group, which can be detected at Em/Ex = 490/520nm. In presence of potent MMP-1 inhibitors the hydrolyzation of substrate will be inhibited or stopped. The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of MMP-1 inhibitors. For comparison of the relative efficacy of test inhibitors, a control inhibitor, GM 6001 (IC50 = 0.4 nM for MMP-1) is included. |
| 同种亚型 | Rabbit IgG |
| 来源宿主 | Rabbit |
性能| 供应商 | Biovision |
| 检测类型 | Fluorescence (Ex/Em 490/520 nm) • Sample type- Test inhibitors for MMP-1• Applications- The kit can be used to screen inhibitors of MMP-1 |
| 产品特色 | • Simple procedure; takes ~35-45 minutes • Fast and convenient • The assay is simple, reliable and ensures accuracy and consistency when working with multiple samples |
| 试剂盒组分 | • Assay Buffer • Substrate • MMP-1 Enzyme • Inhibitor Control (5 µM GM 6001) |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
