TACE Inhibitor Screening Assay Kit ( Fluorometric)
货号：
K366-100 基本售价：
5947.5 元 规格：
100assays
产品信息
概述| 货号 | K366-100 |
| 描述 | The TACE (tumor necrosis factor-α-converting enzyme), also called ADAM metallopeptidase domain 17 (ADAM17), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. TACE is believed to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as shedding, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance. In BioVision’s TACE inhibitor screening Kit, TACE hydrolyzes the specific FRET substrate to release the quenched fluorescent group, which can be detected fluorometrically at Ex/Em = 318/449 nm. In the presence of the potent TACE inhibitor, the hydrolyzation of substrate will be impeded. The kit provides a rapid, simple, sensitive and reliable test suitable for high-throughput screening of TACE inhibitors and can be modified to check the relative TACE activity. Inhibitor Control GM6001 is included to compare the efficacy of test inhibitors. |
| 同种亚型 | Rabbit IgG |
| 来源宿主 | Rabbit |
性能| 供应商 | Biovision |
| 检测类型 | Fluorescence (Ex/Em 318/449 nm)• Species reactivity- Mammalian • Applications- Suitable for high-throughput screening of TACE inhibitor and can be modified to check the relative TACE activity. Inhibitor control GM6001 is included to c |
| 产品特色 | • Simple procedure• Fast and convenient • The assay is sensitive, stable and high-throughput adaptable. |
| 试剂盒组分 | • TACE Assay Buffer• TACE Substrate• TACE Enzyme (20 μg)• Inhibitor Control (0.1 mM GM6001) |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
