Neutrophil Elastase Inhibitor Screening Kit (Fluorometric)
货号：
K782-100 基本售价：
5403.0 元 规格：
100assays
产品信息
概述| 货号 | K782-100 |
| 描述 | Neutrophil Elastase (NE) is an aggressive and cytotoxic 29 kDa serine protease stored mainly in the azurophil granules of neutrophil granulocytes. It plays a role in the degradation of a wide range of extracellular matrix proteins, including fibronectin, laminin, proteoglycans, collagens, and elastin. When the extracellular NE concentration exceeds the buffering capacity of endogenous inhibitors, it becomes implicated in the signs, symptoms and disease progression of inflammatory lung disorders via its role in the inflammatory process, mucus overproduction and lung tissue damage. In BioVision’s Neutrophil Elastase Inhibitor Screening Kit, NE hydrolyzes a specific fluorescent substrate to release the fluorescent group, which can be detected at Ex/Em = 400/505 nm. In presence of a potent Neutrophil Elastase inhibitor, the hydrolyzation of substrate will be inhibited or stopped. The kit provides a rapid, simple, sensitive, and reliable test suitable as a high throughput screening assay of Neutrophil Elastase inhibitors. For comparison of the relative efficacy of test inhibitors, a control inhibitor, SPCK (Ki = 10 µM for human leukocyte elastase) is included. |
| 同种亚型 | Rabbit IgG |
| 来源宿主 | Rabbit |
性能| 供应商 | Biovision |
| 检测类型 | Fluorescence (Ex/Em 400/505 nm) • Sample type- Neutrophil elastase (NE) inhibitor test compounds • Applications- This kit can be used for screening NE inhibitors and comes along with control inhibitors |
| 产品特色 | • Simple procedure; takes ~40 minutes • Fast and convenient • Sensitive assay for screening various NE candidate compounds |
| 试剂盒组分 | • Assay Buffer • Substrate • Neutrophil Elastase • Inhibitor Control (3 mM, SPCK) |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
