FABP4 Inhibitor/Ligand Screening Assay Kit
货号：
10010231-1ea 基本售价：
3556.0 元 规格：
1 ea
产品信息
概述| 货号 | 10010231-1ea |
| 描述 | Fatty acid binding protein 4 (Adipocyte-FABP, aP2, FABP4) is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids.1 FABP4 is highly expressed in adipocytes and is regulated by peroxisome-proliferator-activated receptor-γ (PPARγ) agonists, insulin and fatty acids. Recent studies using FABP4 gene deletion in mice indicate a dominant role for FABP4 in several chronic metabolic diseases. Therefore, inhibiting the function of FABP4 is a potential mechanism for the treatment of metabolic diseases like diabetes and atherosclerosis.2,3 Cayman’s FABP4 Ligand Binding Assay Kit provides a simple, reproducible, and sensitive tool for the identification of FABP4 ligands. The assay makes use of a Detection Reagent that exhibits increased fluorescence at 500 nm when bound to FABP4. Any strong ligand and/or inhibitor of FABP4 will displace the Detection Reagent thereby reducing the fluorescence. FABP4 is provided in high purity and in sufficient quantity for 100 tests. |
| 别名 | Adipocyte FABP;A-FABP;ALBP;aP2;Fatty Acid Binding Protein 4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cellular and Molecular Life Sciences 59, 1096-1116 (2002).
2.Furuhashi, M.,Tuncman, G.,Görgün, C.Z., et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447, 959-965 (2007).
3.Boord, J.B.,Maeda, K.,Makowski, L., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology 22, 1686-1691 (2002).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 1 year |
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