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货号： bs-6222R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6222R-Cy5.5
- 英文名称
- Anti-THRA1+2/Cy5.5
- 中文名称
- Cy5.5标记的甲状腺激素受体α1+α2抗体
- 别 名
- Thyroid Hormone Receptor alpha 1+2; THRA1+THRA2; AR7; Avian erythroblastic leukemia viral (v erb a) oncogene homolog; c ERBA 1; c ERBA ALPHA 2; C erbA alpha; c-erbA-1; C-erbA-alpha; cerbA protein; cerbAalpha; EAR 7; EAR 7.1; EAR 7.2; EAR-7; EAR7; ERB T 1; ERBA 1; ERBA ALPHA; ERBA; ERBA related 7; ERBA1; Erythroblastic leukemia viral (v erb a) oncogene homolog avian; NR1A 1; Nr1a1; Nuclear receptor subfamily 1 group A member 1; Oncogene ERBA; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (verba) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 神经生物学 信号转导 转录调节因子 内分泌病
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Zebrafish, Sheep, Cat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 55kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human THRA1 and THRA2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function:
Nuclear hormone receptor. High affinity receptor for triiodothyronine.
Subunit:
Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.
Subcellular Location:
Nucleus.
DISEASE:
Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:
UniProtKB/Swiss-Prot: P10827.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.