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货号： bs-6250R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6250R-Cy5.5
- 英文名称
- Anti-DPPL1/Cy5.5
- 中文名称
- Cy5.5标记的磷脂酸磷酸酶HTPAP抗体
- 别 名
- diacylglycerol pyrophosphate like 1; DPPL1; EC=3.1.3.4; HTPAP; Phosphatidate phosphatase PPAPDC1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; PPAPDC1B; PPC1B_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DPPL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DPPL1 and is a 223 amino acid protein that is localized to the cellular membrane. HTPAP is a multi-pass membrane protein which is thought to possess six transmembrane spanning domains and is expressed as two isoforms. HTPAP is a member of the PAP related phosphoesterase family and the gene encoding HTPAP is highly conserved among many species. HTPAP functions as a PAP for lipid phosphate substrates, including PA (phosphatidate), LPA (lysophatidate) and DGPP (diacylglycerol pyrophosphate), but preferentially targets DGPP. Breast cancer tumors, specifically those in which ER (estrogen receptor) is present in high amounts, exhibit upregulation of the gene which encodes HTPAP and HTPAP is thought to increase ER activity. Due to the overexpression of HTPAP in ductal breast carcinomas and the observation that, in cases of lower HTPAP expression, tumors grew slower, HTPAP is thought to be an oncogene. In contrast, the gene encoding HTPAP is downregulated in HCC (hepatocellular carcinoma) and is thought to inhibit lung metastasis.
Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
Subcellular Location:
Membrane; Multi-pass membrane protein
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the PA-phosphatase related phosphoesterase family.
Database links:Entrez Gene: 84513Human
Entrez Gene: 71910Mouse
Entrez Gene: 680466Rat
Omim: 610626Human
SwissProt: Q8NEB5Human
SwissProt: Q3UMZ3Mouse
Unigene: 567619Human
Unigene: 385055Mouse
Unigene: 199008Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.