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Rat IL-10 Quantikine PharmPak (50 Plates) ( )

货号: PR1000 基本售价: 220717.2 元 规格: 1 PACK

产品信息

概述
货号PR1000
描述The Quantikine Rat IL-10 Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-10 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant rat IL-10 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant rat IL-10 accurately. Results obtained using natural rat IL-10 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural rat IL-10.
别名CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF;
全称
Interleukin 10
目标/特异性Natural and recombinant rat IL-10
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 493683 (Feline); 100135553 (Guinea Pig); 2949786 (Viral)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Gene expression profiling and inhibition of adipose tissue accumulation of G. bimaculatus extract in rats on high fat diet.
Authors: Ahn M, Kim M, Kwon R, Hwang J, Park K
Lipids Health Dis, 2015;14(0):116.
Species: Rat
Sample Type: Serum

Non-invasive technology that improves cardiac function after experimental myocardial infarction: Whole Body Periodic Acceleration (pGz).
Authors: Uryash A, Bassuk J, Kurlansky P, Altamirano F, Lopez J, Adams J
PLoS ONE, 2015;10(3):e0121069.
Species: Rat
Sample Type: Tissue Homogenates

Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma.
Authors: Koshy S, Huq R, Tanner M, Atik M, Porter P, Khan F, Pennington M, Hanania N, Corry D, Beeton C
J Biol Chem, 2014;289(18):12623-32.
Species: Rat
Sample Type: BALF

Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: gastroprotective and ulcer healing properties in rats.
Authors: Maria-Ferreira D, da Silva L, Mendes D, Cabrini D, Nascimento A, Iacomini M, Cipriani T, Santos A, Werner M, Baggio C
PLoS ONE, 2014;9(1):e84762.
Species: Rat
Sample Type: Tissue Supernate

Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression.
Authors: Schwarz JM, Hutchinson MR, Bilbo SD
J. Neurosci., 2011;31(49):17835-47.
Species: Rat
Sample Type: Serum

Vipera aspis venom reduces lethality and down-regulates tumor necrosis factor-alpha in a rat model of LPS-induced sepsis.
Authors: Frolkis I, Klein Y, Locker C, Adi N, Dahan E, Uretzsky G, Shapira I, Sorkine P
Cytokine, 2010;49(3):319-24.
Species: Rat
Sample Type: Serum

Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-kappaB activation.
Authors: Song WB, Wang YY, Meng FS, Zhang QH, Zeng JY, Xiao LP, Yu XP, Peng DD, Su L, Xiao B, Zhang ZS
PLoS ONE, 2010;5(9):e12969.
Species: Rat
Sample Type: Plasma

Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes.
Authors: Hu AP, Du JM, Li JY, Liu JW
Inflamm. Res., 2008;57(4):163-70.
Species: Rat
Sample Type: Cell Culture Supernates

Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis.
Authors: Ke Y, Jiang G, Sun D, Kaplan HJ, Shao H
Invest. Ophthalmol. Vis. Sci., 2008;49(9):3999-4007.
Species: Rat
Sample Type: Aqueous humor

Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol.
Authors: de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT
Am. J. Physiol., Cell Physiol., 2007;293(3):C1120-8.
Species: Rat
Sample Type: BALF

Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model.
Authors: Chang SL, Beltran JA, Swarup S
J. Virol., 2007;81(16):8406-11.
Species: Rat
Sample Type: Serum

Resuscitation from experimental heatstroke by estrogen therapy.
Authors: Chen SH, Chang FM, Niu KC, Lin MY, Lin MT
Crit. Care Med., 2006;34(4):1113-8.
Species: Rat
Sample Type: Serum

Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure.
Authors: Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PS, Star RA
Kidney Int., 2006;70(3):496-506.
Species: Rat
Sample Type: Serum

Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
Authors: Chen CC, Wang SS, Tsay SH, Lee FY, Lu RH, Chang FY, Lee SD
Cytokine, 2006;33(2):95-9.
Species: Rat
Sample Type: Serum

Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.
Authors: Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J
J. Immunol., 2005;174(4):2327-35.
Species: Rat
Sample Type: Cell Culture Supernates

Effects of pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, on cytokine expression and ocular inflammation in experimental autoimmune anterior uveitis.
Authors: Fang IM, Yang CH, Lin CP, Yang CM, Chen MS
J Ocul Pharmacol Ther, 2005;21(2):95-106.
Species: Rat
Sample Type: Aqueous humor

Immunotherapy of murine prostate cancer using whole tumour cells killed ex vivo by cytosine deaminase/5-fluorocytosine suicide-gene therapy.
Authors: Pandha HS, Cook D, Greenhalgh R, Dalgleish A
BJU Int., 2005;95(9):1336-43.
Species: Rat
Sample Type: Cell Culture Supernates

Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat.
Authors: Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B
Crit. Care Med., 2005;33(10):2317-22.
Species: Rat
Sample Type: BALF

Ameliorating effects of the immunomodulator 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole in an experimental model of colitis in the rat.
Authors: Stasi MA, Ruggiero V, Ursillo A, Taurelli R, Agliano M, Weber E, Lorenzoni P, Sorrentino V, Pacifici L, Carminati P
Eur. J. Pharmacol., 2004;494(2):263-72.
Species: Rat
Sample Type: Tissue Homogenates

Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.
Authors: Schubert T, Horch RE
Ann. Surg., 2004;240(2):340-9.
Species: Rat
Sample Type: Tissue Homogenates

Insulin attenuates the systemic inflammatory response in endotoxemic rats.
Authors: Jeschke MG, Klein D, Bolder U, Einspanier R
Endocrinology, 2004;145(9):4084-93.
Species: Rat
Sample Type: Tissue Homogenates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.
运输条件Blue Ice
存放说明4℃
参考文献
  • B Cell Development and Differentiation
  • B Cell Markers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • IL-10/Interferon Family
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Lymphoma
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Monocyte Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • Neuroinflammation
  • Plasmacytoid Dendritic Cells
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells
  • Th2 Cells
  • Th22 Cells
  • Th9 Cells