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Human TNF-alpha HS ELISA SixPak ( )

货号: SSTA00E 基本售价: 40758.6 元 规格: 1 PACK

产品信息

概述
货号SSTA00E
描述The Quantikine HS Human TNF-alpha Immunoassay is a 6.5 hour solid phase ELISA designed to measure TNF-alpha in serum and plasma. It contains E. coli-derived recombinant human TNF-alpha and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human TNF-alpha. Results obtained with naturally occurring TNF-alpha samples showed linear curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural TNF-alpha. Since the measurement of TNF-alpha is insensitive to the addition of recombinant forms of either of the two types of soluble receptors, it is probable that this measurement detects the total amount of TNF-alpha in samples, i.e., the total amount of free TNF-alpha plus the amount of TNF-alpha bound to soluble receptors.
别名APC1 protein; Cachectin; Cachetin; DIF; TNF; TNF, monocyte-derived; tnfa; tnf-a; TNFalpha; TNF-alpha; TNF-alphacachectin; TNFATNF, macrophage-derived; TNFSF1A; TNFSF2; TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor-alpha;
全称
Tumor Necrosis Factor alpha
目标/特异性Natural and recombinant human TNF-alpha
性能
供应商R&D Systems
Entrez Gene IDs
7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia
Authors: K Tanisawa, H Taniguchi, X Sun, T Ito, R Kawakami, S Sakamoto, M Higuchi
PLoS ONE, 2017;12(3):e0173310.
Species: Human
Sample Type: Serum

Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients
PLoS ONE, 2016;11(8):e0158527.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study.
Authors: Amdur R, Mukherjee M, Go A, Barrows I, Ramezani A, Shoji J, Reilly M, Gnanaraj J, Deo R, Roas S, Keane M, Master S, Teal V, Soliman E, Yang P, Feldman H, Kusek J, Tracy C, Raj D
PLoS ONE, 2016;11(2):e0148189.
Species: Human
Sample Type: Plasma

Effects of nateglinide and rosiglitazone on pancreatic alpha- and beta-cells, GLP-1 secretion and inflammatory markers in patients with type 2 diabetes: randomized crossover clinical study.
Authors: Tostes G, Cunha M, Fukui R, Correia M, Rocha D, Dos Santos R, da Silva M
Diabetol Metab Syndr, 2016;8(0):1.
Species: Human
Sample Type: Serum

Circadian misalignment increases cardiovascular disease risk factors in humans
Proc. Natl. Acad. Sci. U.S.A., 2016;113(10):E1402-11.
Species: Human
Sample Type: Serum

Anti-TNF-? Drugs Differently Affect the TNF?-sTNFR System and Monocyte Subsets in Patients with Psoriasis
PLoS ONE, 2016;11(12):e0167757.

Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
Authors: Dominique Girard
PLoS ONE, 2016;11(6):e0156329.
Species: Human
Sample Type: Serum

The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women
Authors: GY Na, SR Yoon, J An, R Yeo, J Song, MN Jo, S Han, OY Kim
Endocr. J, 2016;0(0):.
Species: Human
Sample Type: Plasma

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
J Clin Invest, 2016;0(0):.
Species: Human
Sample Type: Serum

Casein glycomacropeptide for active distal ulcerative colitis: a randomised pilot study
Authors: CL Hvas, A Dige, M Bendix, PG Wernlund, LA Christense, JF Dahlerup, J Agnholt
Eur J Clin Invest, 2016;0(0):.
Species: Human
Sample Type: Plasma

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.
Authors: Ziegler D, Strom A, Strassburger K, Nowotny B, Zahiragic L, Nowotny P, Carstensen-Kirberg M, Herder C, Szendroedi J, Roden M
PLoS ONE, 2015;10(4):e0124242.
Species: Human
Sample Type: Serum

Tumor necrosis factor-alpha confers cardioprotection through ectopic expression of keratins K8 and K18.
Authors: Papathanasiou S, Rickelt S, Soriano M, Schips T, Maier H, Davos C, Varela A, Kaklamanis L, Mann D, Capetanaki Y
Nat Med, 2015;21(9):1076-84.
Species: Human
Sample Type: Serum

Disturbances in Hypothalamic-Pituitary-Adrenal Axis and Immunological Activity Differentiating between Unipolar and Bipolar Depressive Episodes.
Authors: Becking K, Spijker A, Hoencamp E, Penninx B, Schoevers R, Boschloo L
PLoS ONE, 2015;10(7):e0133898.
Species: Human
Sample Type: Plasma

Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients.
Authors: Almroth G, Lonn J, Uhlin F, Brudin L, Andersson B, Hahn-Zoric M
Scand J Immunol, 2015;83(1):58-63.
Species: Human
Sample Type: Serum

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.
Authors: Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari N, Koch M, Saadati M, Benner A, Buchler M, Jager D, Halama N, Khazaie K, Weitz J, Beckhove P
J Clin Invest, 2015;125(2):739-51.
Species: Human
Sample Type: Tissue Homogenates

Association of Sarcopenic Obesity with Higher Serum High-Sensitivity C-Reactive Protein Levels in Chinese Older Males--A Community-Based Study (Taichung Community Health Study-Elderly, TCHS-E).
Authors: Yang C, Li C, Li T, Liu C, Lin C, Lin W, Lin C
PLoS ONE, 2015;10(7):e0132908.
Species: Human
Sample Type: Serum

Effects of Acute Endurance Exercise Performed in the Morning and Evening on Inflammatory Cytokine and Metabolic Hormone Responses.
Authors: Kim H, Konishi M, Takahashi M, Tabata H, Endo N, Numao S, Lee S, Kim Y, Suzuki K, Sakamoto S
PLoS ONE, 2015;10(9):e0137567.
Species: Human
Sample Type: Plasma

Effects of pentoxifylline on proteinuria and glucose control in patients with type 2 diabetes: a prospective randomized double-blind multicenter study.
Authors: Han S, Kim H, Kim D, Sheen S, Chung C, Ahn C, Kim S, Cho Y, Park S, Kim S, Kim C, Kim K, Lee K
Diabetol Metab Syndr, 2015;7(0):64.
Species: Human
Sample Type: Serum

Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study.
Authors: Gupta J, Dominic E, Fink J, Ojo A, Barrows I, Reilly M, Townsend R, Joffe M, Rosas S, Wolman M, Patel S, Keane M, Feldman H, Kusek J, Raj D
PLoS ONE, 2015;10(4):e0124772.
Species: Human
Sample Type: Plasma

Plasma TNF-alpha and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
Authors: Hayslip J, Dressler E, Weiss H, Taylor T, Chambers M, Noel T, Miriyala S, Keeney J, Ren X, Sultana R, Vore M, Butterfield D, St Clair D, Moscow J
PLoS ONE, 2015;10(4):e0124988.
Species: Human
Sample Type: Plasma

A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism.
Authors: Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, Genore L, Zaghloul D, Iaboni A, Marcon P, Anagnostou E
Mol Autism, 2015;6(0):18.
Species: Human
Sample Type: Plasma

Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study.
Authors: Wing M, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman N, Reilly M, Wolman M, Rosas S, Cuevas M, Fischer M, Lustigova E, Master S, Xie D, Appleby D, Joffe M, Kusek J, Feldman H, Raj D
Obesity (Silver Spring), 2014;22(5):1359-66.
Species: Human
Sample Type: Plasma

Role of diacylglycerol activation of PKCtheta in lipid-induced muscle insulin resistance in humans.
Authors: Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Muller J, Herder C, Nowotny P, Shulman G, Roden M
Proc Natl Acad Sci U S A, 2014;111(26):9597-602.
Species: Human
Sample Type: Plasma

Zinc supplementation improves anticancer activity of monocytes in type-2 diabetic patients with metabolic syndrome.
Authors: Meksawan K, Sermsri U, Chanvorachote P
Anticancer Res, 2014;34(1):295-9.
Species: Human
Sample Type: Plasma

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.
Authors: Wellman T, Eckenstein M, Wong C, Rincon M, Ashikaga T, Mount S, Francklyn C, Lounsbury K
BMC Cancer, 2014;14(0):620.
Species: Human
Sample Type: Serum

The protective effect of esculentoside a on experimental acute liver injury in mice.
Authors: Zhang F, Wang X, Qiu X, Wang J, Fang H, Wang Z, Sun Y, Xia Z
PLoS ONE, 2014;9(11):e113107.
Species: Human
Sample Type: cell culture supernate

Compartment differences of inflammatory activity in chronic obstructive pulmonary disease.
Authors: Ji J, von Scheele I, Bergstrom J, Billing B, Dahlen B, Lantz A, Larsson K, Palmberg L
Respir Res, 2014;15(0):104.
Species: Human
Sample Type: Serum

Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study.
Authors: Teichert T, Vossoughi M, Vierkotter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Kramer U
PLoS ONE, 2013;8(12):e83042.
Species: Human
Sample Type: Plasma

Adipocytokine levels mark endothelial function in normotensive individuals.
Authors: Solini A, Stea F, Santini E, Bruno R, Duranti E, Taddei S, Ghiadoni L
Cardiovasc Diabetol, 2012;11(0):103.
Species: Human
Sample Type: Plasma

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
Blood, 2012;120(19):4058-67.
Species: Human
Sample Type: Serum

A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury.
Authors: Paine R, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC
Crit. Care Med., 2012;40(1):90-7.
Species: Human
Sample Type: BALF

Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Authors: Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, Buch MH, McDermott MF, Ponchel F
Clin. Exp. Rheumatol., 2012;30(4):534-42.
Species: Human
Sample Type: Serum

Fractalkine is an independent predictor of mortality in patients with advanced heart failure.
Thromb Haemost, 2012;108(6):1220-7.
Species: Human
Sample Type: Plasma

Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study.
Authors: Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, Paniagua JA, Golabek-Leszczynska I, Defoort C, Williams CM, Karsltrom B, Vessby B, Dembinska-Kiec A, Lopez-Miranda J, Blaak EE, Drevon CA, Gibney MJ, Lovegrove JA, Roche HM
Int J Obes (Lond), 2011;35(6):800-9.
Species: Human
Sample Type: Serum

Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
Authors: Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C
PLoS ONE, 2011;6(7):e22748.
Species: Human
Sample Type: Plasma

Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans.
Authors: Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A
J. Bone Miner. Res., 2011;26(8):1891-903.
Species: Human
Sample Type: Serum

Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
Authors: Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M
Mol. Cell Proteomics, 2010;9(2):327-35.
Species: Human
Sample Type: Plasma

Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients.
Authors: Rhind SG, Crnko NT, Baker AJ
J Neuroinflammation, 2010;7(0):5.
Species: Human
Sample Type: Serum

Procalcitonin as an early marker of bacterial infection in neutropenic febrile children with acute lymphoblastic leukemia.
Authors: Hatzistilianou M, Rekliti A, Athanassiadou F, Catriu D
Inflamm. Res., 2010;59(5):339-47.
Species: Human
Sample Type: Serum

B7-h3 augments the inflammatory response and is associated with human sepsis.
Authors: Zhang G, Wang J, Kelly J
J. Immunol., 2010;185(6):3677-84.
Species: Human
Sample Type: Plasma

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Authors: Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M
Diabetes, 2010;59(4):829-35.
Species: Human
Sample Type: Plasma

Nonalcoholic fatty liver disease as the transducer of hepatic oversecretion of very-low-density lipoprotein-apolipoprotein B-100 in obesity.
Authors: Chan DC, Watts GF, Gan S
Arterioscler. Thromb. Vasc. Biol., 2010;30(5):1043-50.
Species: Human
Sample Type: Plasma

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
Atherosclerosis, 2010;210(2):536-41.
Species: Human
Sample Type: Plasma

Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers.
Authors: Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D, Corthier G, Dore J, Henegar C, Rizkalla S, Clement K
Diabetes, 2010;59(12):3049-57.
Species: Human
Sample Type: Plasma

Age-dependent mobilization of circulating endothelial progenitor cells in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.
Authors: Sun Y, Yi D, Wang Y, Zheng R, Sun G, Wang J, Liu Y, Ren J, Wang Y, Zhang S, Gu C, Pei J
Cytokine, 2009;47(3):206-13.
Species: Human
Sample Type: Plasma

Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
Authors: Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, Spector TD
Arthritis Rheum., 2009;60(7):2037-45.
Species: Human
Sample Type: Serum

Smoking, inflammatory patterns and postprandial hypertriglyceridemia.
Authors: Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, Glasser SP, Arnett DK
Atherosclerosis, 2009;203(2):633-9.
Species: Human
Sample Type: Serum

Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
Diabetes Care, 2009;32(3):486-92.
Species: Human
Sample Type: Serum

Adiposity and gingival crevicular fluid tumour necrosis factor-alpha levels in children.
Authors: Khosravi R, Tran SD, Lambert M, OLoughlin J, Kâ K, Feine JS, Caron C, Tremblay A, Nicolau B
J. Clin. Periodontol., 2009;36(4):301-7.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses.
Authors: Glass-Marmor L, Paperna T, Galboiz Y, Miller A
J. Neuroimmunol., 2009;210(1):124-7.
Species: Human
Sample Type: Serum

Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness.
Authors: Jaiyen Y, Masrinoul P, Kalayanarooj S, Pulmanausahakul R, Ubol S
Microbiol. Immunol., 2009;53(8):442-50.
Species: Human
Sample Type: Plasma

The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy.
Authors: Venkateswaran RV, Dronavalli V, Lambert PA, Steeds RP, Wilson IC, Thompson RD, Mascaro JG, Bonser RS
Transplantation, 2009;88(4):582-8.
Species: Human
Sample Type: Serum

Sex differences in inflammatory markers: what is the contribution of visceral adiposity?
Authors: Cartier A, Cote M, Lemieux I, Perusse L, Tremblay A, Bouchard C, Despres JP
Am. J. Clin. Nutr., 2009;89(5):1307-14.
Species: Human
Sample Type: Plasma

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
Authors: Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H
Arthritis Rheum., 2009;60(6):1615-23.
Species: Human
Sample Type: Serum

Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
Authors: Frankel DS, Vasan RS, DAgostino RB, Benjamin EJ, Levy D, Wang TJ, Meigs JB
J. Am. Coll. Cardiol., 2009;53(9):754-62.
Species: Human
Sample Type: Plasma

Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner.
Authors: Redmond EM, Morrow D, Kundimi S, Miller-Graziano CL, Cullen JP
Atherosclerosis, 2009;204(2):372-80.
Species: Human
Sample Type: Cell Culture Supernates

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
Authors: Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW
Cancer Lett., 2009;283(1):29-35.
Species: Human
Sample Type: Serum

In vivo transmigrated monocytes from patients with stable coronary artery disease have a reduced expression of CD11b.
Authors: Paulsson JM, Dadfar E, Held C, Jacobson SH, Lundahl J
Clin. Exp. Immunol., 2008;153(2):196-204.
Species: Human
Sample Type: Serum

Neutropenia in 6 ethnic groups from the Caribbean and the U.S.
Authors: Grann VR, Bowman N, Joseph C, Wei Y, Horwitz MS, Jacobson JS, Santella RP, Hershman DL
Cancer, 2008;113(4):854-60.
Species: Human
Sample Type: Plasma

Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.
Authors: Grann VR, Ziv E, Joseph CK, Neugut AI, Wei Y, Jacobson JS, Horwitz MS, Bowman N, Beckmann K, Hershman DL
Br. J. Haematol., 2008;143(2):288-93.
Species: Human
Sample Type: Plasma

Duffy antigen modifies the chemokine response in human endotoxemia.
Authors: Mayr FB, Spiel AO, Leitner JM, Firbas C, Kliegel T, Jilma-Stohlawetz P, Derendorf H, Jilma B
Crit. Care Med., 2008;36(1):159-65.
Species: Human
Sample Type: Plasma

Low-dose acetylsalicylic acid inhibits the secretion of interleukin-6 from white adipose tissue.
Authors: Ogston NC, Karastergiou K, Hosseinzadeh-Attar MJ, Bhome R, Madani R, Stables M, Gilroy D, Flachs P, Hensler M, Kopecky J, Mohamed-Ali V
Int J Obes (Lond), 2008;32(12):1807-15.
Species: Human
Sample Type: Plasma

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma.
Authors: Hothersall EJ, Chaudhuri R, McSharry C, Donnelly I, Lafferty J, McMahon AD, Weir CJ, Meiklejohn J, Sattar N, McInnes I, Wood S, Thomson NC
Thorax, 2008;63(12):1070-5.
Species: Human
Sample Type: Serum

Identification of interleukin-7 as a candidate disease mediator in spondylarthritis.
Authors: Rihl M, Kellner H, Kellner W, Barthel C, Yu DT, Tak PP, Zeidler H, Baeten D
Arthritis Rheum., 2008;58(11):3430-5.
Species: Human
Sample Type: Synovial Fluid

Self-esteem levels and cardiovascular and inflammatory responses to acute stress.
Authors: ODonnell K, Brydon L, Wright CE, Steptoe A
Brain Behav. Immun., 2008;0(0):.
Species: Human
Sample Type: Plasma

Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
Authors: Denollet J, Vrints CJ, Conraads VM
Brain Behav. Immun., 2008;22(5):736-43.
Species: Human
Sample Type: Plasma

Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD.
Authors: Vogiatzis I, Stratakos G, Simoes DC, Terzis G, Georgiadou O, Roussos C, Zakynthinos S
Thorax, 2007;62(11):950-6.
Species: Human
Sample Type: Plasma

Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis.
Authors: Koivisto H, Hietala J, Anttila P, Niemela O
Dig. Dis. Sci., 2007;53(2):500-5.
Species: Human
Sample Type: Serum

Cerebrospinal fluid IL-6, HSP72, and TNF-alpha in exercising humans.
Authors: Steensberg A, Dalsgaard MK, Secher NH, Pedersen BK
Brain Behav. Immun., 2006;20(6):585-9.
Species: Human
Sample Type: Plasma

The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children.
Authors: Mysliwiec M, Zorena K, Balcerska A, Mysliwska J, Lipowski P, Raczynska K
Clin. Biochem., 2006;39(8):851-6.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.

Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

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参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Co-stimulatory and Co-inhibitory Molecules
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • EMT Induction
  • gamma delta T Cells
  • Inflammatory Mediators
  • Inflammatory/Monocyte-derived Dendritic Cells
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Natural Killer T (NKT) Cells
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • Preeclampsia
  • Regulation of Apoptosis by TNF Superfamily Members
  • Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
  • Regulation of T Cell Co-stimulation by TNF Superfamily Members
  • T Cell Cytokine Signaling
  • Th1 Cells
  • Th22 Cells
  • TNF Superfamily Ligands