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Human IL-1 beta Quantikine HS SixPak (6 Plates) ( )

货号: SSLB00D 基本售价: 37625.6 元 规格: 1 PACK

产品信息

概述
货号SSLB00D
描述The Quantikine HS Human IL-1 beta Immunoassay is a 4 hour solid phase ELISA designed to measure human IL-1 beta levels in serum, plasma, and saliva. It contains E. coli-expressed recombinant human IL-1 beta and antibodies raised against the recombinant factor and has been shown to accurately quantitate recombinant human IL-1 beta. Results obtained using natural IL-1 beta showed linear curves that were parallel to the standard curves obtained using the Quantikine HS kit standards. These results indicate that the Quantikine HS Immunoassay kit can be used to determine relative mass values for natural human IL-1 beta. Reports indicate that ELISA kits calibrated using mature IL-1 beta as a standard will detect, but considerably underestimate, the unprocessed IL-1 beta precursor present in samples. In biological samples other than cell lysates, the precursor form of IL-1 beta is usually not the predominant form of IL-1 beta present and, additionally, is not biologically active. Therefore, results obtained using this kit should provide a useful measure of the levels of active IL-1 beta present in serum, plasma, and saliva.
别名catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta;
全称
Interleukin 1 beta
目标/特异性Natural and recombinant human IL-1 beta. This assay also recognizes recombinant rhesus macaque IL-1 beta (aa 117-269).
性能
供应商R&D Systems
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
Authors: HY Tan, YK Yong, EM Shankar, G Paukovics, R Ellegård, M Larsson, A Kamarulzam, MA French, SM Crowe
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Plasma

Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study.
Authors: Gupta J, Dominic E, Fink J, Ojo A, Barrows I, Reilly M, Townsend R, Joffe M, Rosas S, Wolman M, Patel S, Keane M, Feldman H, Kusek J, Raj D
PLoS ONE, 2015;10(4):e0124772.
Species: Human
Sample Type: Plasma

Effects of Acute Endurance Exercise Performed in the Morning and Evening on Inflammatory Cytokine and Metabolic Hormone Responses.
Authors: Kim H, Konishi M, Takahashi M, Tabata H, Endo N, Numao S, Lee S, Kim Y, Suzuki K, Sakamoto S
PLoS ONE, 2015;10(9):e0137567.
Species: Human
Sample Type: Plasma

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging"
Authors: Pinti M, Cevenini E, Nasi M, De Biasi S, Salvioli S, Monti D, Benatti S, Gibellini L, Cotichini R, Stazi M, Trenti T, Franceschi C, Cossarizza A
Eur J Immunol, 2014;44(5):1552-62.
Species: Human
Sample Type: Plasma

Endothelial activation by platelets from sickle cell anemia patients.
Authors: Proenca-Ferreira R, Brugnerotto A, Garrido V, Dominical V, Vital D, Ribeiro M, dos Santos M, Traina F, Olalla-Saad S, Costa F, Conran N
PLoS ONE, 2014;9(2):e89012.
Species: Human
Sample Type: cell supernates

Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study.
Authors: Wing M, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman N, Reilly M, Wolman M, Rosas S, Cuevas M, Fischer M, Lustigova E, Master S, Xie D, Appleby D, Joffe M, Kusek J, Feldman H, Raj D
Obesity (Silver Spring), 2014;22(5):1359-66.
Species: Human
Sample Type: Plasma

Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study.
Authors: Beghe B, Verduri A, Bottazzi B, Stendardo M, Fucili A, Balduzzi S, Leuzzi C, Papi A, Mantovani A, Fabbri L, Ceconi C, Boschetto P
PLoS ONE, 2013;8(11):e80166.
Species: Human
Sample Type: Plasma

The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis.
Authors: Ngan D, Wilcox P, Aldaabil M, Li Y, Leipsic J, Sin D, Man S
BMC Pulm Med, 2012;12(0):3.
Species: Human
Sample Type: Plasma

Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Authors: Verma S, Kumar M, Nerurkar VR
J. Gen. Virol., 2011;92(0):507-15.
Species: Human
Sample Type: Cell Culture Supernates

Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome.
Authors: Schneider MP, Schlaich MP, Harazny JM, Raff U, Ritt M, Ott C, Schmieder RE
Obesity (Silver Spring), 2011;19(5):960-7.
Species: Human
Sample Type: Plasma

Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
Authors: Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C
PLoS ONE, 2011;6(7):e22748.
Species: Human
Sample Type: Plasma

Maternal IL-1beta production prevents lung injury in a mouse model of bronchopulmonary dysplasia.
Authors: Backstrom E, Lappalainen U, Bry K
Am. J. Respir. Cell Mol. Biol., 2010;42(2):149-60.
Species: Human
Sample Type: Plasma

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
Atherosclerosis, 2010;210(2):536-41.
Species: Human
Sample Type: Plasma

Interleukin-1beta, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis.
Authors: Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P
J. Interferon Cytokine Res., 2010;30(11):835-42.
Species: Human
Sample Type: Serum

Procalcitonin as an early marker of bacterial infection in neutropenic febrile children with acute lymphoblastic leukemia.
Authors: Hatzistilianou M, Rekliti A, Athanassiadou F, Catriu D
Inflamm. Res., 2010;59(5):339-47.
Species: Human
Sample Type: Serum

Positive affect and inflammation during radiation treatment for breast and prostate cancer.
Authors: Sepah SC, Bower JE
Brain Behav. Immun., 2009;23(8):1068-72.
Species: Human
Sample Type: Serum

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
Authors: Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW
Cancer Lett., 2009;283(1):29-35.
Species: Human
Sample Type: Serum

The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy.
Authors: Venkateswaran RV, Dronavalli V, Lambert PA, Steeds RP, Wilson IC, Thompson RD, Mascaro JG, Bonser RS
Transplantation, 2009;88(4):582-8.
Species: Human
Sample Type: Serum

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Authors: Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T
J. Exp. Med., 2009;206(5):1029-36.
Species: Human
Sample Type: Plasma

Two large preoperative doses of erythropoietin do not reduce the systemic inflammatory response to cardiac surgery.
Authors: Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV
J. Cardiothorac. Vasc. Anesth., 2009;23(3):316-23.
Species: Human
Sample Type: Plasma

Correlation between salivary IL-1beta levels and periodontal clinical status.
Authors: Tobon-Arroyave S, Jaramillo-Gonzalez P, Isaza-Guzman D
Arch Oral Biol, 2008;53(4):346-52.
Species: Human
Sample Type: Saliva

The influence of anger expression on wound healing.
Authors: Gouin JP, Kiecolt-Glaser JK, Malarkey WB, Glaser R
Brain Behav. Immun., 2007;22(5):699-708.
Species: Human
Sample Type: Wound Secretion

Defining cancer cachexia in head and neck squamous cell carcinoma.
Authors: Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG
Clin. Cancer Res., 2007;13(22):6561-7.
Species: Human
Sample Type: Serum

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Clin. Cancer Res., 2006;12(2):376-82.
Species: Human
Sample Type: Plasma

Increased interleukin-18 in patients with juvenile idiopathic arthritis and early attachment loss.
Authors: Miranda LA, Fischer RG, Sztajnbok FR, Johansson A, Figueredo CM, Gustafsson A
J. Periodontol., 2005;76(1):75-82.
Species: Human
Sample Type: Serum

Markers of inflammation in exhaled breath condensate of young healthy smokers.
Authors: Garey KW, Neuhauser MM, Robbins RA, Danziger LH, Rubinstein I
Chest, 2004;125(1):22-6.
Species: Human
Sample Type: Exhaled Breath Condensate (EBC)

The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
Authors: Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE
Immunity, 2003;18(1):87-96.
Species: Human
Sample Type: Serum

Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Authors: Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ
Am. J. Pathol., 2003;163(6):2347-70.
Species: Primate - Macaca fascicularis (Crab-eating or Cynomolgus macaque)
Sample Type: Serum

Impact of an exercise-induced increase in cardiac troponin I in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Authors: Schulz O, Sigusch HH
Am. J. Cardiol., 2002;90(5):547-50.
Species: Human
Sample Type: Serum

Cytokine production in rhesus monkeys infected with Plasmodium coatneyi.
Authors: Yang C, Xiao L, Tongren JE, Sullivan J, Lal AA, Collins WE
Am. J. Trop. Med. Hyg., 1999;61(2):226-9.
Species: Primate
Sample Type: Serum

生物活性Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • IL-1 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells