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Human FGF basic Quantikine HS SixPak (6 Plates) (1 PK)

货号: SSFB00D 基本售价: 37625.6 元 规格: 1 PACK

产品信息

概述
货号SSFB00D
描述The Quantikine HS Human FGF basic Immunoassay kit is a 5.5 hour solid phase ELISA designed to measure FGF basic levels in serum, plasma, and urine. It contains E. coli-expressed recombinant human FGF basic and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human FGF basic accurately. Results obtained using natural human FGF basic showed linear curves that were parallel to the standard curves obtained using the Quantikine HS kit standards. These results indicate that this kit can be used to determine relative mass values for natural human FGF basic.
别名basic fibroblast growth factor bFGF; Basic fibroblast growth factor; bFGF; FGF basic; FGF2; FGF-2; FGF2AS; FGFBprostatropin; fibroblast growth factor 2 (basic); GFG1; HBGF-2; HBGH-2; heparin-binding growth factor 2; NUDT6; Prostatropin;
全称
Fibroblast Growth Factor basic
反应种属Human
目标/特异性Natural and recombinant human FGF basic
性能
供应商R&D Systems
Entrez Gene IDs
2247 (Human); 14173 (Mouse); 281161 (Bovine); 403857 (Canine); 100033955 (Equine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study.
Authors: Briasoulis, Evangelo, Aravantinos, Gerasimo, Kouvatseas, George, Pappas, Periklis, Biziota, Eirini, Sainis, Ioannis, Makatsoris, Thomas, Varthalitis, Ioannis, Xanthakis, Ioannis, Vassias, Antonios, Klouvas, George, Boukovinas, Ioannis, Fountzilas, George, Syrigos, Kostanti, Kalofonos, Haralamb, Samantas, Epaminon
BMC Cancer, 2013;13(1):263.
Species: Human
Sample Type: Plasma

Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma.
Authors: Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J, Pallota MG, Zarba JJ, Boyer M, Riordan S, Strickland A, Tebbutt N, Thomson B, Borbath I, De Greve J, Van Laethem J-, Van Steenbergen W, Van Vlierberghe H, Barrios C, Cosme de Oliveira A, Kotzev I, Takov D, Tchernev K, Burak K, Ma M, Metrakos P, Olweny C, Sherman M, Gamargo Garate C, Martinez-Castillo J, Beaugrand M, Bennouna J, Blanc J-, Bronowicki J-, Degos F, Dominguez S, Grange J-, Hillon P, Raoul J-, Seitz J-, Blum H, Buggisch P, Caspary W, Dollinger M, Gerken G, Goke B, Gregor M, Greten T, Haussinger D, Hilgard P, Scherübl J, Scheulen M, Schmid R, Spengler U, Wiest R, Zeuzem S, Arvanitakis C, Germanidis G, Katsos I, Figer A, Stemmer S, Amadori D, Bolondi L, Cognetti F, Craxi A, Farinati F, Gridelli C, Martoni A, Mazzaferro V, Porta C, Ricci S, Sangiovanni A, Santoro A, Trevisani F, Cisnero Garza LE, Gane E, ODonnell A, Leon J, Lozano A, Jassem J, Rydzewska G, Szawlowski A, Tomczak P, Badulescu F, Miron L, Kubyshkin V, Bruix J, Forner A, Bustamante Schneider J, Diago M, Montero Alvarez JL, Pascual S, Ruíz del Arbol L, Sangro B, Solá R, Tabernero J, Muellhaupt B, Roth A, Jeffry Evans TR, Falk S, Meyer T, Reeves H, Ross P, Befeler A, Boyer T, Britten C, Byrne T, Garcia-Tsao G, Gold P, Goldenberg A, Heuman D, Kennedy P, Koch A, Llovet JM, Marrero J, Schilsky M, Schwartz J, Schwartz M
Clin. Cancer Res., 2012;18(8):2290-300.
Species: Human
Sample Type: Plasma

Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans.
Authors: Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J, Koch KT, Horrevoets AJ, Hoefer IE, Piek JJ
J. Am. Coll. Cardiol., 2009;53(23):2141-7.
Species: Human
Sample Type: Plasma

Oncogenic and angiogenic growth factors accumulate during routine storage of apheresis platelet concentrates.
Authors: Kanter J, Khan SY, Kelher M, Gore L, Silliman CC
Clin. Cancer Res., 2008;14(12):3942-7.
Species: Human
Sample Type: Platelet-Poor Plasma

Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
Authors: Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM
Pediatr. Res., 2007;61(1):32-6.
Species: Ovine
Sample Type: Serum

Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity.
Authors: Anagnostopoulos A, Eleftherakis-Papaiakovou V, Kastritis E, Tsionos K, Bamias A, Meletis J, Dimopoulos MA, Terpos E
Br. J. Haematol., 2007;137(6):560-8.
Species: Human
Sample Type: Serum

Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factor.
Authors: Schneider P, Vasse M, Corbiere C, Legrand E, Marie-Cardine A, Boquet C, Cazin L, Vannier JP
Leuk. Res., 2007;31(5):629-38.
Species: Human
Sample Type: Plasma

Dedicated epithelial recipient cells determine pigmentation patterns.
Authors: Weiner L, Han R, Scicchitano BM, Li J, Hasegawa K, Grossi M, Lee D, Brissette JL
Cell, 2007;130(5):932-42.
Species: Mouse
Sample Type: Cell Culture Supernates

Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.
Authors: Kulke MH, Bergsland EK, Ryan DP, Enzinger PC, Lynch TJ, Zhu AX, Meyerhardt JA, Heymach JV, Fogler WE, Sidor C, Michelini A, Kinsella K, Venook AP, Fuchs CS
J. Clin. Oncol., 2006;24(22):3555-61.
Species: Human
Sample Type: Urine

Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis.
Authors: Bourlev V, Larsson A, Olovsson M
Am. J. Obstet. Gynecol., 2006;194(3):755-9.
Species: Human
Sample Type: Peritoneal Fluid

Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.
Authors: Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, Lebwohl D, Masson E, Ho YY, Gunther C, Laurent D, Unger C
Eur. J. Cancer, 2005;41(9):1291-9.
Species: Human
Sample Type: Plasma

Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release.
Authors: Lacoste E, Martineau I, Gagnon G
J. Periodontol., 2003;74(10):1498-507.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxel.
Authors: Huang SF, Kim SJ, Lee AT, Karashima T, Bucana C, Kedar D, Sweeney P, Mian B, Fan D, Shepherd D, Fidler IJ, Dinney CP, Killion JJ
Cancer Res., 2002;62(20):5720-6.
Species: Mouse
Sample Type: Serum

Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies.
Authors: Esner M, Pachernik J, Hampl A, Dvorak P
Int. J. Dev. Biol., 2002;46(6):817-25.
Species: Bovine
Sample Type: Serum

High urine concentrations of basic fibroblast growth factor in dogs with bladder cancer.
Authors: Allen DK, Waters DJ, Knapp DW, Kuczek T
J. Vet. Intern. Med., 1996;10(4):231-4.
Species: Canine
Sample Type: Whole Cells

High urine concentrations of basic fibroblast growth factor in dogs with bladder cancer.
Authors: Allen DK, Waters DJ, Knapp DW, Kuczek T
J. Vet. Intern. Med., 1996;10(4):231-4.
Species: Canine
Sample Type: Urine

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景FGF basic (FGF-2) is a growth factor that functions in angiogenesis, wound healing, tissue repair, learning and memory, and the morphogenesis of heart, bone, and brain. It is upregulated in response to inflammatory stimuli and in many tumors. FGF basic binds to FGF R1c and 2c. Its bioactivity is modulated by a number of other binding partners including heparin, Integrin alpha V beta 3, soluble FGF R1, FGF-BP, free gangliosides, Thrombospondin, Pentraxin 3/TSG-14, Fibrinogen, alpha 2-Macroglobulin, PDGF, and CXCL4/PF4. These molecules act as cellular coreceptors or adhesion partners, extracellular matrix decoys or reservoirs, and soluble scavengers or chaperones. In particular, the interaction of FGF basic with cell surface heparan sulfate proteoglycans (HSPG) is required for the binding and activation of FGF receptors.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adult Neurogenesis
  • Cancer Biomarkers
  • Developmental Factors Implicated in Neurodegeneration
  • EMT Induction
  • FGF Family
  • FGF Ligands