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Human IL-10 Quantikine HS SixPak (6 Plates) (1 PK)

货号: SS100C 基本售价: 37625.6 元 规格: 1 PACK

产品信息

概述
货号SS100C
描述The Quantikine HS Human IL-10 Immunoassay is a 5.5 hour solid phase ELISA designed to measure IL-10 in serum and plasma. It contains Sf 21-expressed recombinant human IL-10 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human IL-10. Results obtained using natural human IL-10 showed linear curves that are parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-10.
别名CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF;
全称
Interleukin 10
反应种属Human
目标/特异性Natural and recombinant human IL-10
性能
供应商R&D Systems
Entrez Gene IDs
3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 493683 (Feline); 100135553 (Guinea Pig); 2949786 (Viral)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Aberrant expression of interleukin-10 in rheumatoid arthritis: Relationship with IL10 haplotypes and autoantibodies
Authors: J Hernández-, E Oregón-Rom, M Vázquez-Vi, S García-Are, Y Valle, JR Padilla-Gu, IV Román-Fern, CA Palafox-Sá, GE Martínez-B, JF Muñoz-Vall
Cytokine, 2017;95(0):88-96.
Species: Human
Sample Type: Serum

Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity
Authors: I Bergström, AK Lundberg, S Jönsson, E Särndahl, J Ernerudh, L Jonasson
PLoS ONE, 2017;12(3):e0174177.
Species: Human
Sample Type: Plasma

Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome.
Authors: Johansson A, Alfredsson J, Eriksson N, Wallentin L, Siegbahn A
PLoS ONE, 2015;10(11):e0142518.
Species: Human
Sample Type: Plasma

Mucosal effects of tenofovir 1% gel.
Authors: Hladik F, Burgener A, Ballweber L, Gottardo R, Vojtech L, Fourati S, Dai J, Cameron M, Strobl J, Hughes S, Hoesley C, Andrew P, Johnson S, Piper J, Friend D, Ball T, Cranston R, Mayer K, McElrath M, McGowan I
Elife, 2015;4(0):.
Species: Human
Sample Type: Cell Culture Supernates

Acute phase IL-10 plasma concentration associates with the high risk sources of cardiogenic stroke.
Authors: Arponen O, Muuronen A, Taina M, Sipola P, Hedman M, Jakala P, Vanninen R, Pulkki K, Mustonen P
PLoS ONE, 2015;10(4):e0120910.
Species: Human
Sample Type: Plasma

Whole-Body UVB Irradiation during Allogeneic Hematopoietic Cell Transplantation Is Safe and Decreases Acute Graft-versus-Host Disease.
Authors: Kreutz M, Karrer S, Hoffmann P
J. Invest. Dermatol., 2012;132(1):179-87.
Species: Human
Sample Type: Serum

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, OKane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
Authors: Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C
PLoS ONE, 2011;6(7):e22748.
Species: Human
Sample Type: Plasma

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
Atherosclerosis, 2010;210(2):536-41.
Species: Human
Sample Type: Plasma

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Authors: Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M
Diabetes, 2010;59(4):829-35.
Species: Human
Sample Type: Plasma

Two large preoperative doses of erythropoietin do not reduce the systemic inflammatory response to cardiac surgery.
Authors: Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV
J. Cardiothorac. Vasc. Anesth., 2009;23(3):316-23.
Species: Human
Sample Type: Plasma

Age-dependent mobilization of circulating endothelial progenitor cells in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.
Authors: Sun Y, Yi D, Wang Y, Zheng R, Sun G, Wang J, Liu Y, Ren J, Wang Y, Zhang S, Gu C, Pei J
Cytokine, 2009;47(3):206-13.
Species: Human
Sample Type: Plasma

Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
Diabetes Care, 2009;32(3):486-92.
Species: Human
Sample Type: Serum

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
Authors: Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF
Ann. Surg., 2008;247(2):320-6.
Species: Human
Sample Type: Plasma

Duffy antigen modifies the chemokine response in human endotoxemia.
Authors: Mayr FB, Spiel AO, Leitner JM, Firbas C, Kliegel T, Jilma-Stohlawetz P, Derendorf H, Jilma B
Crit. Care Med., 2008;36(1):159-65.
Species: Human
Sample Type: Plasma

In vivo transmigrated monocytes from patients with stable coronary artery disease have a reduced expression of CD11b.
Authors: Paulsson JM, Dadfar E, Held C, Jacobson SH, Lundahl J
Clin. Exp. Immunol., 2008;153(2):196-204.
Species: Human
Sample Type: Serum

Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis.
Authors: Koivisto H, Hietala J, Anttila P, Niemela O
Dig. Dis. Sci., 2007;53(2):500-5.
Species: Human
Sample Type: Serum

The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children.
Authors: Mysliwiec M, Zorena K, Balcerska A, Mysliwska J, Lipowski P, Raczynska K
Clin. Biochem., 2006;39(8):851-6.
Species: Human
Sample Type: Serum

Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia.
Authors: Leitner JM, Firbas C, Mayr FB, Reiter RA, Steinlechner B, Jilma B
Clin. Pharmacol. Ther., 2006;79(1):23-34.
Species: Human
Sample Type: Plasma

Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report.
Authors: Bozkurt FY, Yetkin Ay Z, Berker E, Tepe E, Akkus S
Cytokine, 2006;35(3):180-5.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease.
Authors: Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G
Blood, 2006;107(10):4142-8.
Species: Human
Sample Type: Serum

Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection.
Authors: Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G
Transpl. Int., 2005;18(2):177-85.
Species: Human
Sample Type: Plasma

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
Authors: Jensen J, Krakauer M, Sellebjerg F
Cytokine, 2005;29(1):24-30.
Species: Human
Sample Type: Plasma

Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy.
Authors: Hernandez C, Segura RM, Fonollosa A, Carrasco E, Francisco G, Simo R
Diabet. Med., 2005;22(6):719-22.
Species: Human
Sample Type: Vitreous Humor

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Immunodetection of a hepatitis C virus (HCV) antigen and Thl/Th2 cytokines in cerebrospinal fluid of meningitis patients.
Authors: Attallah AM, Ibrahim GG
J Immunoassay Immunochem, 2004;25(4):313-20.
Species: Human
Sample Type: Serum

Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.
Authors: Schieffer B, Bunte C, Witte J, Hoeper K, Boger RH, Schwedhelm E, Drexler H
J. Am. Coll. Cardiol., 2004;44(2):362-8.
Species: Human
Sample Type: Serum

Escape from cardiomyocyte apoptosis by enterovirus persistence due to elevated soluble Fas-receptors.
Authors: Alter P, Maisch B
Z Kardiol, 2004;93(7):524-32.
Species: Human
Sample Type: Serum

Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis.
Authors: Benson M, Strannegard IL, Wennergren G, Strannegard O
Pediatr Allergy Immunol, 2000;11(1):20-8.
Species: Human
Sample Type: nasal lavage

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.
运输条件Blue Ice
存放说明4℃
参考文献
  • B Cell Development and Differentiation
  • B Cell Markers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • IL-10/Interferon Family
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Lymphoma
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Monocyte Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • Neuroinflammation
  • Plasmacytoid Dendritic Cells
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells
  • Th2 Cells
  • Th22 Cells
  • Th9 Cells