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Human IL-6 QuantiGlo SixPak (6 Plates) (1 PK)

货号: SQ6000B 基本售价: 37625.6 元 规格: 1 PACK

产品信息

概述
货号SQ6000B
描述The QuantiGlo Human IL-6 Chemiluminescent Immunoassay is a solid phase ELISA that specifically measures human IL-6 in less than 5.5 hours. This kit is designed to measure IL-6 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-6 and antibodies raised against the recombinant factor. It has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-6 showed linear curves that were parallel to the standard curves obtained using the QuantiGlo kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-6. It has been observed in our laboratories that the measurement of human IL-6 is insensitive to the addition of the recombinant form of the human IL-6 soluble receptor.
别名B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A;
全称
Interleukin 6
反应种属Human
目标/特异性Natural and recombinant human IL-6
性能
供应商R&D Systems
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity
Authors: I Bergström, AK Lundberg, S Jönsson, E Särndahl, J Ernerudh, L Jonasson
PLoS ONE, 2017;12(3):e0174177.
Species: Human
Sample Type: Plasma

Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus
Cytokine, 2016;90(0):109-112.
Species: Human
Sample Type: Serum

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy
PLoS ONE, 2016;11(5):e0155100.
Species: Human
Sample Type: Plasma

Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange
Authors: K Crothers, I Petrache, C Wongtrakoo, PJ Lee, LM Schnapp, SA Gharib
Physiol Rep, 2016;4(8):.
Species: Human
Sample Type: Serum

N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for Loss of Muscle Mass in Prevalent Hemodialysis Patients
PLoS ONE, 2016;11(11):e0166804.
Species: Human
Sample Type: Serum

Factors associated with D-dimer levels in HIV-infected individuals.
Authors: Borges A, OConnor J, Phillips A, Baker J, Vjecha M, Losso M, Klinker H, Lopardo G, Williams I, Lundgren J
PLoS ONE, 2014;9(3):e90978.
Species: Human
Sample Type: Plasma

A pilot study of telmisartan for visceral adiposity in HIV infection: the metabolic abnormalities, telmisartan, and HIV infection (MATH) trial.
Authors: Lake J, Tseng C, Currier J
PLoS ONE, 2013;8(3):e58135.
Species: Human
Sample Type: Serum

Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue.
Authors: Cifuentes M, Fuentes C, Tobar N, Acevedo I, Villalobos E, Hugo E, Ben-Jonathan N, Reyes M
Mol Cell Endocrinol, 2012;361(1):24-30.
Species: Human
Sample Type: Cell Culture Supernates

Inflammation, coagulation and cardiovascular disease in HIV-infected individuals.
Authors: Duprez, Daniel A, Neuhaus, Jacqueli, Kuller, Lewis H, Tracy, Russell, Belloso, Waldo, De Wit, Stephane, Drummond, Fraser, Lane, H Cliffo, Ledergerber, Bruno, Lundgren, Jens, Nixon, Daniel, Paton, Nicholas, Prineas, Ronald J, Neaton, James D
PLoS ONE, 2012;7(9):e44454.
Species: Human
Sample Type: Plasma

Angiotensin converting enzyme inhibitor and HMG-CoA reductase inhibitor as adjunct treatment for persons with HIV infection: a feasibility randomized trial.
Authors: Baker J, Huppler Hullsiek K, Prosser R, Duprez D, Grimm R, Tracy R, Rhame F, Henry K, Neaton J
PLoS ONE, 2012;7(10):e46894.
Species: Human
Sample Type: Plasma

Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects.
Authors: Fung MM, Rao F, Poddar S
Am. J. Hypertens., 2011;24(2):225-33.
Species: Human
Sample Type: Plasma

Activation of nuclear factor-kappa B signalling promotes cellular senescence.
Authors: Rovillain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema RH, Hummerich H, Jat PS
Oncogene, 2011;30(20):2356-66.
Species: Human
Sample Type: Cell Culture Supernates

Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies.
Authors: Karlson EW, Chibnik LB, Tworoger SS, Lee IM, Buring JE, Shadick NA, Manson JE, Costenbader KH
Arthritis Rheum., 2009;60(3):641-52.
Species: Human
Sample Type: Plasma

Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.
Authors: Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM, Hauguel-De Mouzon S
Placenta, 2008;29(3):274-81.
Species: Human
Sample Type: Plasma

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study.
Authors: Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, Chen S, Cosentino L, Curtis K, Dezzutti CS, Donoval B, Doncel GF, Donaghay M, Grivel JC, Guzman E, Hayes M, Herold B, Hillier S, Lackman-Smith C, Landay A, Margolis L, Mayer KH, Pasicznyk JM, Pallansch-Cokonis M, Poli G, Reichelderfer P, Roberts P, Rodriguez I, Saidi H, Sassi RR, Shattock R, Cummins JE
Anal. Chem., 2008;80(12):4741-51.
Species: Human
Sample Type: WHO 89/548 reference standard

Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes.
Authors: Fritzenwanger M, Meusel K, Foerster M, Kuethe F, Krack A, Figulla HR
Cytokine, 2007;38(3):137-44.
Species: Human
Sample Type: Cell Culture Supernates

Usefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatin.
Authors: Lee TM, Lin MS, Chang NC
Am. J. Cardiol., 2007;101(4):530-5.
Species: Human
Sample Type: Plasma

Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkins lymphoma.
Authors: Feldmann G, Nischalke HD, Nattermann J, Banas B, Berg T, Teschendorf C, Schmiegel W, Duhrsen U, Halangk J, Iwan A, Sauerbruch T, Caselmann WH, Spengler U
Clin. Cancer Res., 2006;12(15):4491-8.
Species: Human
Sample Type: Serum

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in Nagano, Japan: clinical, radiological, and cytokine studies of 13 patients.
Authors: Oide T, Ohara S, Oguchi K, Maruyama M, Yazawa M, Inoue K, Sekijima Y, Tokuda T, Ikeda S
Clin. Exp. Rheumatol., 2004;22(1):91-8.
Species: Human
Sample Type: Serum

Procalcitonin and proinflammatory cytokine clearance during continuous venovenous haemofiltration in septic patients.
Authors: Dahaba AA, Elawady GA, Rehak PH, List WF
Anaesth Intensive Care, 2002;30(3):269-74.
Species: Human
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • gamma delta T Cells
  • Glucose Homeostasis
  • Helper T (Th) Cells
  • HIF Transcription Factors
  • IL-6 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Multiple Myeloma
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells
  • Th9 Cells