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Human IFN-beta ELISA Kit, FivePak (1 KT)

货号: 41410-2 基本售价: 35434.5 元 规格: 1 PACK

产品信息

概述
货号41410-2
简介NEW Human IFN-beta Quantikine ELISA Kit is now available, catalog # DIFNB0
别名Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956;
全称
Interferon beta
反应种属Human
目标/特异性Human IFN-beta
性能
供应商R&D Systems
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5
PLoS ONE, 2016;11(8):e0160875.
Species: Human
Sample Type: Cell Culture Supernates

Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner
Authors: M Tatematsu, R Yoshida, Y Morioka, N Ishii, K Funami, A Watanabe, K Saeki, T Seya, M Matsumoto
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
Proc Natl Acad Sci USA, 2016;113(38):10625-10630.
Species: Human
Sample Type: Cell Culture Supernates

A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer.
Authors: Hosein A, Livingstone J, Buchanan M, Reid J, Hallett M, Basik M
BMC Cancer, 2015;15(0):130.
Species: Human
Sample Type: Cell Culture Supernates

NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
Authors: Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S
Eur J Immunol, 2015;45(3):758-72.
Species: Human
Sample Type: cell supernates

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
J Virol, 2015;89(7):3859-69.

Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium.
Authors: Villenave R, Broadbent L, Douglas I, Lyons J, Coyle P, Teng M, Tripp R, Heaney L, Shields M, Power U
J Virol, 2015;89(24):12309-18.
Species: Human
Sample Type: Cell Culture Supernates

Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses.
Authors: Wu Z, Sinzger C, Reichel J, Just M, Mertens T
J Virol, 2015;89(5):2906-17.
Species: Human
Sample Type: Cell Culture Supernates

The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection.
Authors: Zhang Y, Yeruva L, Marinov A, Prantner D, Wyrick P, Lupashin V, Nagarajan U
J Immunol, 2014;193(5):2394-404.
Species: Human
Sample Type: cell supernates

Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling.
Authors: Xia, Mao, Gonzalez, Patrick, Li, Chunyan, Meng, Gang, Jiang, Aiqin, Wang, Hongwei, Gao, Qian, Debatin, Klaus-Mi, Beltinger, Christia, Wei, Jiwu
J Virol, 2014;88(9):5152-64.
Species: Human
Sample Type: Cell Culture Supernates

HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-beta induction in cervical epithelial cells.
Authors: Liu H, Chen K, Feng W, Guo J, Li H
PLoS ONE, 2014;9(4):e94806.

Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells.
Authors: Stone, Amy E L, Giugliano, Silvia, Schnell, Gretja, Cheng, Linling, Leahy, Katelyn, Golden-Mason, Lucy, Gale, Michael, Rosen, Hugo R
PLoS Pathog, 2013;9(4):e1003316.
Species: Human
Sample Type: cell culture supernate

Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.
Authors: Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I
J Virol, 2012;86(20):11183-93.
Species: Human
Sample Type: Cell Culture Supernates

Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.
Authors: Patel MV, Ghosh M, Fahey JV, Wira CR
PLoS ONE, 2012;7(4):e35654.
Species: Human
Sample Type: Cell Culture Supernates

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010;115(24):5041-52.
Species: Human
Sample Type: Cell Culture Supernates

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Authors: Wang P, Arjona A, Zhang Y
Nat. Immunol., 2010;11(10):912-9.
Species: Mouse
Sample Type: Plasma

Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4.
Authors: Chase JC, Celli J, Bosio CM
Infect. Immun., 2009;77(1):180-95.
Species: Human
Sample Type: Cell Culture Supernates

Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans.
Authors: Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J, Koch KT, Horrevoets AJ, Hoefer IE, Piek JJ
J. Am. Coll. Cardiol., 2009;53(23):2141-7.
Species: Human
Sample Type: Plasma

The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
Authors: Lee SH, Kim JS, Jun HK
J. Immunol., 2009;182(9):5823-35.
Species: Human
Sample Type: Cell Lysates

Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
J. Allergy Clin. Immunol., 2009;124(2):260-9, 269.e1.
Species: Human
Sample Type: Serum

Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
Clin. Exp. Immunol., 2007;147(1):71-80.
Species: Human
Sample Type: Serum

Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.
Authors: Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(4):L1021-8.
Species: Human
Sample Type: Cell Culture Supernates

APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.
Authors: Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ
J. Immunol., 2004;172(1):138-43.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.
Authors: Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M
J. Gen. Virol., 2004;85(0):2603-13.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.
运输条件Blue Ice
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参考文献
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Angiogenesis
  • IL-10/Interferon Family
  • Infectious Diseases
  • Plasmacytoid Dendritic Cells
  • Th9 Cells