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Human VEGF R2/KDR Quantikine SixPak (6 Plates) (1 PK)

货号: SVR200 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SVR200
描述The Quantikine Human VEGF R2 Immunoassay is a 4.5 hour solid-phase Immunoassay designed to measure human soluble VEGF R2 in cell culture supernates, cell lysates, serum, and plasma. It contains NS0-expressed recombinant human VEGF R2/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human VEGF R2 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human soluble VEGF R2.
别名CD309 antigen; CD309; EC 2.7.10; EC 2.7.10.1; Fetal liver kinase 1; fetal liver kinase-1; Flk1; Flk-1; FLK1tyrosine kinase growth factor receptor; KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; vascular endothelial growth factor receptor 2; VEGF R2; VEGFR; VEGFR2; VEGFR-2;
全称
Vascular Endothelial Growth Factor Receptor 2
反应种属Human
目标/特异性Natural and recombinant human VEGF R2
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3791 (Human); 16542 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features.
Authors: Salazar R, Capdevila J, Laquente B, Manzano J, Pericay C, Villacampa M, Lopez C, Losa F, Safont M, Gomez A, Alonso V, Escudero P, Gallego J, Sastre J, Gravalos C, Biondo S, Palacios A, Aranda E
BMC Cancer, 2015;15(0):60.
Species: Human
Sample Type: Plasma

Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
Br J Cancer, 2014;110(1):26-33.
Species: Human
Sample Type: Plasma

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer.
Authors: Sallinen H, Heikura T, Koponen J, Kosma V, Heinonen S, Yla-Herttuala S, Anttila M
BMC Cancer, 2014;14(0):696.
Species: Human
Sample Type: Serum

Dasatinib plus capecitabine for advanced breast cancer: safety and efficacy in phase I study CA180004.
Authors: Somlo G, Atzori F, Strauss L, Geese W, Specht J, Gradishar W, Rybicki A, Sy O, Vahdat L, Cortes J
Clin Cancer Res, 2013;19(7):1884-93.
Species: Human
Sample Type: Plasma

Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study.
Authors: Briasoulis, Evangelo, Aravantinos, Gerasimo, Kouvatseas, George, Pappas, Periklis, Biziota, Eirini, Sainis, Ioannis, Makatsoris, Thomas, Varthalitis, Ioannis, Xanthakis, Ioannis, Vassias, Antonios, Klouvas, George, Boukovinas, Ioannis, Fountzilas, George, Syrigos, Kostanti, Kalofonos, Haralamb, Samantas, Epaminon
BMC Cancer, 2013;13(1):263.
Species: Human
Sample Type: Plasma

Prognostic and predictive value of VEGF, sVEGFR-2 and CEA in mCRC studies comparing cediranib, bevacizumab and chemotherapy.
Authors: Jurgensmeier J, Schmoll H, Robertson J, Brooks L, Taboada M, Morgan S, Wilson D, Hoff P
Br J Cancer, 2013;108(6):1316-23.
Species: Human
Sample Type: Plasma

A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report.
Authors: Widemann B, Kim A, Fox E, Baruchel S, Adamson P, Ingle A, Glade Bender J, Burke M, Weigel B, Stempak D, Balis F, Blaney S
Clin Cancer Res, 2012;18(21):6011-22.
Species: Human
Sample Type: Plasma

Cytokine and angiogenic factors associated with efficacy and toxicity of pazopanib in advanced soft-tissue sarcoma: an EORTC-STBSG study.
Br. J. Cancer, 2012;107(4):639-45.
Species: Human
Sample Type: Serum

Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
Authors: Loupakis F, Cremolini C, Fioravanti A
Br. J. Cancer, 2011;104(8):1262-9.
Species: Human
Sample Type: Plasma

Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.
Authors: Farace F, Gross-Goupil M, Tournay E, Taylor M, Vimond N, Jacques N, Billiot F, Mauguen A, Hill C, Escudier B
Br. J. Cancer, 2011;104(7):1144-50.
Species: Human
Sample Type: Plasma

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept.
Authors: de Groot JF, Piao Y, Tran H, Gilbert M, Wu HK, Liu J, Bekele BN, Cloughesy T, Mehta M, Robins HI, Lassman A, Deangelis L, Camphausen K, Chen A, Yung W, Prados M, Wen PY, Heymach JV
Clin. Cancer Res., 2011;17(14):4872-4881.
Species: Human
Sample Type: Plasma

Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib.
Authors: Harmon CS, DePrimo SE, Raymond E, Cheng AL, Boucher E, Douillard JY, Lim HY, Kim JS, Lechuga MJ, Lanzalone S, Lin X, Faivre S
J Transl Med, 2011;9(0):120.
Species: Human
Sample Type: Plasma

Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum

Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a childrens oncology group study.
Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
Clin. Cancer Res., 2011;17(15):5113-22.
Species: Human
Sample Type: Plasma

Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
Fertil. Steril., 2010;94(1):52-7.
Species: Human
Sample Type: Serum

Phase I and pharmacological study of the broad-spectrum tyrosine kinase inhibitor JNJ-26483327 in patients with advanced solid tumours.
Authors: Konings IR, de Jonge MJ, Burger H
Br. J. Cancer, 2010;103(7):987-92.
Species: Human
Sample Type: Serum

Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
Authors: Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S
Mol. Ther., 2009;17(2):278-84.
Species: Human
Sample Type: Plasma

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Authors: Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK
J. Clin. Oncol., 2009;27(18):3027-35.
Species: Human
Sample Type: Plasma

Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane.
Authors: Burstein HJ, Elias AD, Rugo HS, Cobleigh MA, Wolff AC, Eisenberg PD, Lehman M, Adams BJ, Bello CL, DePrimo SE, Baum CM, Miller KD
J. Clin. Oncol., 2008;26(11):1810-6.
Species: Human
Sample Type: Plasma

Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy.
Authors: Saltz LB, Rosen LS, Marshall JL, Belt RJ, Hurwitz HI, Eckhardt SG, Bergsland EK, Haller DG, Lockhart AC, Rocha Lima CM, Huang X, DePrimo SE, Chow-Maneval E, Chao RC, Lenz HJ
J. Clin. Oncol., 2007;25(30):4793-9.
Species: Human
Sample Type: Plasma

Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
Authors: Norden-Zfoni A, Desai J, Manola J, Beaudry P, Force J, Maki R, Folkman J, Bello C, Baum C, DePrimo SE, Shalinsky DR, Demetri GD, Heymach JV
Clin. Cancer Res., 2007;13(9):2643-50.
Species: Human
Sample Type: Plasma

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
Authors: Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D
Clin. Sci., 2007;112(1):51-7.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
运输条件Blue Ice
存放说明4℃
参考文献
  • Airway Inflammation and Remodeling
  • Cancer Biomarkers
  • Cytokine and Growth Factor Receptors on VSMC
  • Endothelial Cell Differentiation Markers
  • Endothelial Cell Markers
  • Endothelial Progenitor and Endothelial Cell Markers
  • Endothelial Progenitor Cell Markers
  • Hemangioblasts
  • Hematopoietic Stem Cell Markers
  • HIF Transcription Factors
  • Myeloid-derived Suppressor Cells (MDSC)
  • Platelets
  • Receptor Tyrosine Kinases (RTKs)
  • Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
  • Receptors in the Jak/STAT Pathway
  • Semaphorins, Plexin Receptors, and Related Molecules
  • VEGF Family
  • VEGF Receptors and Regulators on Endothelial Cells