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Human Total Adiponectin/Acrp30 Quantikine SixPak (6 Plates) (1 PK)

货号: SRP300 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SRP300
描述The Quantikine Human Total Adiponectin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure total (low, middle, and high molecular weight) human Adiponectin in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human Adiponectin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Adiponectin showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Adiponectin.
别名ACDC; Acrp30; ACRP30ADPN; adipocyte, C1Q and collagen domain containing; Adiponectin; adiponectin, C1Q and collagen domain containing; AdipoQ; ADIPQTL1; ApM1; apM-1; APM1APM-1; C1q and collagen domain-containing protein; GBP28; GBP28apM1; Gelatin-binding protein;
反应种属Human
目标/特异性Natural and recombinant human total Adiponectin (low, middle, and high molecular weight)
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
9370 (Human); 11450 (Mouse); 246253 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the obesity paradox
Authors: R Ito, S Narita, M Huang, T Nara, K Numakura, K Takayama, H Tsuruta, A Maeno, M Saito, T Inoue, N Tsuchiya, S Satoh, T Habuchi
PLoS ONE, 2017;12(2):e0171615.
Species: Human
Sample Type: Serum

Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification
Authors: E Jorge-Gala, C Posadas-Ro, M Torres-Tam, AX Medina-Urr, MA Rodas-D¡az, R Posadas-S , G Vargas-Ala, MD Gonz lez-S, GC Cardoso-Sa, JG Ju rez-Roj
Dis. Markers, 2016;2016(0):9085474.
Species: Human
Sample Type: Serum

Subclinical Inflammation and Endothelial Dysfunction in Young Patients with Diabetes: A Study from United Arab Emirates
PLoS ONE, 2016;11(7):e0159808.
Species: Human
Sample Type: Serum

Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients
Authors: S Vachatova, C Andrys, J Krejsek, M Salavec, K Ettler, V Rehacek, E Cermakova, A Malkova, Z Fiala, L Borska
J Immunol Res, 2016;2016(0):5380792.
Species: Human
Sample Type: Serum

Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration.
Authors: LeCaire T, Palta M
J Diabetes Res, 2015;2015(0):730407.
Species: Human
Sample Type: Plasma

Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss.
Authors: Gaborit B, Abdesselam I, Kober F, Jacquier A, Ronsin O, Emungania O, Lesavre N, Alessi M, Martin J, Bernard M, Dutour A
Int J Obes (Lond), 2015;39(3):480-7.
Species: Human
Sample Type: Plasma

comparative study of glucose homeostasis, lipids and lipoproteins, HDL functionality, and cardiometabolic parameters in modestly severely obese African Americans and White Americans with prediabetes: implications for the metabolic paradoxes.
Authors: Healy S, Osei K, Gaillard T
Diabetes Care, 2015;38(2):228-35.
Species: Human
Sample Type: Serum

The effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for patients with diabetes and subclinical depression: results of a randomized controlled trial.
Authors: Hermanns N, Schmitt A, Gahr A, Herder C, Nowotny B, Roden M, Ohmann C, Kruse J, Haak T, Kulzer B
Diabetes Care, 2015;38(4):551-60.
Species: Human
Sample Type: Serum

Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance.
Authors: Medina-Urrutia A, Posadas-Romero C, Posadas-Sanchez R, Jorge-Galarza E, Villarreal-Molina T, Gonzalez-Salazar M, Cardoso-Saldana G, Vargas-Alarcon G, Torres-Tamayo M, Juarez-Rojas J
Cardiovasc Diabetol, 2015;14(0):20.
Species: Human
Sample Type: Serum

Adverse Fat Depots and Marrow Adiposity Are Associated With Skeletal Deficits and Insulin Resistance in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation.
Authors: Mostoufi-Moab S, Magland J, Isaacoff E, Sun W, Rajapakse C, Zemel B, Wehrli F, Shekdar K, Baker J, Long J, Leonard M
J Bone Miner Res, 2015;30(9):1657-66.
Species: Human
Sample Type: Serum

Circulating adipokines and insulin resistance in subjects with combined cardiac and metabolic syndrome X.
Authors: Liang K, Lee W, Lee W, Liao Y, Wang K, Lee I, Wang J, Sheu W
Diabetol Metab Syndr, 2015;7(0):83.
Species: Human
Sample Type: Serum

Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes.
Authors: Scoditti E, Massaro M, Carluccio M, Pellegrino M, Wabitsch M, Calabriso N, Storelli C, De Caterina R
PLoS ONE, 2015;10(6):e0128218.
Species: Human
Sample Type: Cell Culture Supernates

Adiponectin and bariatric surgery: associations with diabetes and cardiovascular disease in the Swedish Obese Subjects Study.
Authors: Herder C, Peltonen M, Svensson P, Carstensen M, Jacobson P, Roden M, Sjostrom L, Carlsson L
Diabetes Care, 2014;37(5):1401-9.
Species: Human
Sample Type: Serum

Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells.
Authors: Carstensen M, Wiza C, Rohrig K, Fahlbusch P, Roden M, Herder C, Ouwens D
PLoS ONE, 2014;9(1):e85906.
Species: Human
Sample Type: Cell Culture Supernates

Obesity and IL-6 interact in modulating the response to endotoxemia in mice.
Cytokine, 2013;61(1):71-7.
Species: Mouse
Sample Type: Plasma

Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study.
Authors: Teichert T, Vossoughi M, Vierkotter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Kramer U
PLoS ONE, 2013;8(12):e83042.
Species: Human
Sample Type: Plasma

A prospective study of circulating adipokine levels and risk of multiple myeloma.
Authors: Hofmann J, Liao L, Pollak M, Wang Y, Pfeiffer R, Baris D, Andreotti G, Lan Q, Landgren O, Rothman N, Purdue M
Blood, 2012;120(22):4418-20.
Species: Human
Sample Type: Plasma

Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study.
Authors: Kelly AS, Metzig AM, Rudser KD, Fitch AK, Fox CK, Nathan BM, Deering MM, Schwartz BL, Abuzzahab MJ, Gandrud LM, Moran A, Billington CJ, Schwarzenberg SJ
Obesity (Silver Spring), 2012;20(2):364-70.
Species: Human
Sample Type: Plasma

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, OKane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner.
Authors: Lira FS, Pimentel GD, Santos RV, Oyama LM, Damaso AR, Oller do Nascimento CM, Viana VA, Boscolo RA, Grassmann V, Santana MG, Esteves AM, Tufik S, de Mello MT
Lipids Health Dis, 2011;10(0):113.
Species: Human
Sample Type: Plasma

Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks.
Authors: Nanda S, Savvidou M, Syngelaki A, Akolekar R, Nicolaides KH
Prenat. Diagn., 2011;31(2):135-41.
Species: Human
Sample Type: Serum

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
Br. J. Cancer, 2011;104(1):51-9.
Species: Human
Sample Type: Serum

Adipocytokines and CD34 progenitor cells in Alzheimer's disease.
Authors: Bigalke B, Schreitmuller B, Sopova K, Paul A, Stransky E, Gawaz M, Stellos K, Laske C
PLoS ONE, 2011;6(5):e20286.
Species: Human
Sample Type: Plasma

Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study.
Authors: Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, Paniagua JA, Golabek-Leszczynska I, Defoort C, Williams CM, Karsltrom B, Vessby B, Dembinska-Kiec A, Lopez-Miranda J, Blaak EE, Drevon CA, Gibney MJ, Lovegrove JA, Roche HM
Int J Obes (Lond), 2011;35(6):800-9.
Species: Human
Sample Type: Serum

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
Authors: Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF
Am. J. Clin. Nutr., 2010;91(4):1044-59.
Species: Human
Sample Type: Plasma

Nonalcoholic fatty liver disease as the transducer of hepatic oversecretion of very-low-density lipoprotein-apolipoprotein B-100 in obesity.
Authors: Chan DC, Watts GF, Gan S
Arterioscler. Thromb. Vasc. Biol., 2010;30(5):1043-50.
Species: Human
Sample Type: Plasma

Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers.
Authors: Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D, Corthier G, Dore J, Henegar C, Rizkalla S, Clement K
Diabetes, 2010;59(12):3049-57.
Species: Human
Sample Type: Plasma

Adiponectin and its association with bone mass accrual in childhood.
Authors: Sayers A, Timpson NJ, Sattar N, Deanfield J, Hingorani AD, Davey-Smith G, Tobias JH
J. Bone Miner. Res., 2010;25(10):2212-20.
Species: Human
Sample Type: Plasma

Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Authors: Bunck MC, Diamant M, Eliasson B, Corner A, Shaginian RM, Heine RJ, Taskinen MR, Yki-Jarvinen H, Smith U
Diabetes Care, 2010;33(8):1734-7.
Species: Human
Sample Type: Serum

Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role.
Authors: Marousi S, Theodorou G, Karakantza M, Papathanasopoulos P, Ellul J
Acta Neurol. Scand., 2010;121(4):277-84.
Species: Human
Sample Type: Serum

Are there socioeconomic inequalities in cardiovascular risk factors in childhood, and are they mediated by adiposity? Findings from a prospective cohort study.
Authors: Howe LD, Galobardes B, Sattar N
Int J Obes (Lond), 2010;34(7):1149-59.
Species: Human
Sample Type: Plasma

First-trimester prediction of gestational diabetes mellitus: examining the potential of combining maternal characteristics and laboratory measures.
Authors: Savvidou M, Nelson SM, Makgoba M, Messow CM, Sattar N, Nicolaides K
Diabetes, 2010;59(12):3017-22.
Species: Human
Sample Type: Serum

Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.
Authors: Bhutani S, Klempel MC, Berger RA, Varady KA
Obesity (Silver Spring), 2010;18(11):2152-9.
Species: Human
Sample Type: Plasma

Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
Authors: Frankel DS, Vasan RS, DAgostino RB, Benjamin EJ, Levy D, Wang TJ, Meigs JB
J. Am. Coll. Cardiol., 2009;53(9):754-62.
Species: Human
Sample Type: Plasma

Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose.
Authors: Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LM, Randeva HS, Pinkney JH, Wilding JP
Diabetes, 2009;58(8):1780-8.
Species: Human
Sample Type: Serum

HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial.
Authors: Calmy A, Gayet-Ageron A, Montecucco F, Nguyen A, Mach F, Burger F, Ubolyam S, Carr A, Ruxungtham K, Hirschel B, Ananworanich J,
AIDS, 2009;23(8):929-39.
Species: Human
Sample Type: Plasma

Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany.
Authors: Nagel G, Arnold FJ, Wilhelm M, Link B, Zoellner I, Koenig W
Eur. Heart J., 2009;30(15):1885-93.
Species: Human
Sample Type: Plasma

Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity.
Authors: Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E
Fertil. Steril., 2009;91(5):1837-41.
Species: Human
Sample Type: Follicular Fluid

Serial changes in adiponectin and BNP in ACS patients: paradoxical associations with each other and with prognosis.
Authors: Ang DS, Welsh P, Watt P, Nelson SM, Struthers A, Sattar N
Clin. Sci., 2009;117(1):41-8.
Species: Human
Sample Type: Plasma

Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease.
Authors: Miller M, Cho JY, Pham A, Ramsdell J, Broide DH
J. Immunol., 2009;182(1):684-91.
Species: Human
Sample Type: BALF

Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
Diabetes Care, 2009;32(3):486-92.
Species: Human
Sample Type: Serum

Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
Authors: Prior SL, Gable DR, Cooper JA, Bain SC, Hurel SJ, Humphries SE, Stephens JW
Eur. Heart J., 2009;30(10):1263-9.
Species: Human
Sample Type: Plasma

Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults.
Authors: Liu E, Meigs JB, Pittas AG, McKeown NM, Economos CD, Booth SL, Jacques PF
J. Nutr., 2009;139(2):329-34.
Species: Human
Sample Type: Plasma

Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults".
Authors: Kanaka-Gantenbein C, Margeli A, Pervanidou P, Sakka S, Mastorakos G, Chrousos GP, Papassotiriou I
Clin. Chem., 2008;54(7):1176-82.
Species: Human
Sample Type: Serum

Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction.
Authors: Savvidou MD, Sotiriadis A, Kaihura C, Nicolaides KH, Sattar N
Clin. Sci., 2008;115(7):219-24.
Species: Human
Sample Type: Plasma

Importance of the high-molecular-mass isoform of adiponectin in improved insulin sensitivity with rosiglitazone treatment in HIV disease.
Authors: Qurashi S, Mynarcik DC, McNurlan MA, Ahn H, Ferris R, Gelato MC
Clin. Sci., 2008;115(6):197-202.
Species: Human
Sample Type: Plasma

Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men.
Authors: Damsgaard CT, Frokiaer H, Andersen AD, Lauritzen L
J. Nutr., 2008;138(6):1061-6.
Species: Human
Sample Type: Plasma

Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.
Authors: Perez-Martinez P, Lopez-Miranda J, Cruz-Teno C, Delgado-Lista J, Jimenez-Gomez Y, Fernandez JM, Gomez MJ, Marin C, Perez-Jimenez F, Ordovas JM
J. Nutr., 2008;138(9):1609-14.
Species: Human
Sample Type: Plasma

Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk.
Authors: Blanco-Colio LM, Martin-Ventura JL, Gomez-Guerrero C, Masramon X, de Teresa E, Farsang C, Gaw A, Gensini G, Leiter LA, Langer A, Egido J
Eur. J. Pharmacol., 2008;586(1):259-65.
Species: Human
Sample Type: Plasma

Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
Authors: Pfleger C, Mortensen HB, Hansen L, Herder C, Roep BO, Hoey H, Aanstoot HJ, Kocova M, Schloot NC
Diabetes, 2008;57(4):929-37.
Species: Human
Sample Type: Serum

Gene expression profiling of human skeletal muscle in response to stabilized weight loss.
Authors: Larrouy D, Barbe P, Valle C, Dejean S, Pelloux V, Thalamas C, Bastard JP, Le Bouil A, Diquet B, Clement K, Langin D, Viguerie N
Am. J. Clin. Nutr., 2008;88(1):125-32.
Species: Human
Sample Type: Plasma

Factors contributing to the risk of cardiovascular disease reflected by plasma adiponectin: data from the coronary risk factors for atherosclerosis in women (CORA) study.
Authors: Zyriax BC, Algenstaedt P, Hess UF, Schoffauer M, Bamberger C, Boeing H, Windler E
Atherosclerosis, 2008;200(2):403-9.
Species: Human
Sample Type: Plasma

Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake.
Authors: Musso G, Gambino R, De Michieli F, Biroli G, Premoli A, Pagano G, Bo S, Durazzo M, Cassader M
Am. J. Clin. Nutr., 2007;86(3):661-71.
Species: Human
Sample Type: Serum

Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure.
Authors: Wannamethee SG, Whincup PH, Lennon L, Sattar N
Arch. Intern. Med., 2007;167(14):1510-7.
Species: Human
Sample Type: Plasma

Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients.
Authors: Ruano J, Lopez-Miranda J, de la Torre R, Delgado-Lista J, Fernandez J, Caballero J, Covas MI, Jimenez Y, Perez-Martinez P, Marin C, Fuentes F, Perez-Jimenez F
Am. J. Clin. Nutr., 2007;86(2):341-6.
Species: Human
Sample Type: Plasma

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
Authors: Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M
J. Clin. Invest., 2007;117(8):2289-301.
Species: Human
Sample Type: Serum

Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients.
Authors: Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Kim JA, Lee Y, Shin EK
Diabetes Care, 2006;29(2):195-201.
Species: Human
Sample Type: Plasma

Adiponectin and leptin in maternal serum, cord blood, and breast milk.
Authors: Weyermann M, Beermann C, Brenner H, Rothenbacher D
Clin. Chem., 2006;52(11):2095-102.
Species: Human
Sample Type: Serum

Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects.
Authors: Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K, Poole RB, Holt RI, Phillips DI, Byrne CD
Diabetologia, 2006;49(1):141-8.
Species: Human
Sample Type: Serum

Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients.
Authors: Lemoine M, Barbu V, Girard PM, Kim M, Bastard JP, Wendum D, Paye F, Housset C, Capeau J, Serfaty L
AIDS, 2006;20(3):387-95.
Species: Human
Sample Type: Serum

Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome.
Authors: Wang TD, Chen WJ, Cheng WC, Lin JW, Chen MF, Lee YT
Am. J. Cardiol., 2006;98(8):1057-62.
Species: Human
Sample Type: Plasma

Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis.
Authors: Iversen PO, Wiig H
Clin. Cancer Res., 2005;11(19):6793-9.
Species: Human
Sample Type: Bone Marrow Fluid

Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism.
Authors: Chan DC, Watts GF, Ng TW, Uchida Y, Sakai N, Yamashita S, Barrett PH
Clin. Chem., 2005;51(3):578-85.
Species: Human
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Adiponectin (also known as Adipocyte complement-related protein of 30 kDa, Acrp30) is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. Adiponectin associates into 70 kDa noncovalently-linked trimers that are disulfide-linked into medium molecular weight hexamers and then into >300 kDa high molecular weight oligomers.

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参考文献
  • Adipocytokines
  • Adipogenesis Markers
  • Cytokines and Receptors in Angiogenesis
  • Glucose Homeostasis
  • Metabolism
  • Obesity