一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Human RAGE Quantikine SixPak (6 Plates) (1 PK)

货号: SRG00 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SRG00
描述The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.
别名AGER; EC 2.7.11.22; MOK protein kinase; MOKMAPK/MAK/MRK overlapping kinase; RAGE; RAGE-1; RAGE1renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; renal tumor antigen;
全称
Receptor for Advanced Glycation End Products
反应种属Human
目标/特异性Natural and recombinant human RAGE
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
177 (Human); 11596 (Mouse); 81722 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016;11(8):e0160153.
Species: Human
Sample Type: Plasma

Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
Authors: Jabaudon M, Blondonnet R, Roszyk L, Pereira B, Guerin R, Perbet S, Cayot S, Bouvier D, Blanchon L, Sapin V, Constantin J
PLoS ONE, 2015;10(8):e0135857.
Species: Human
Sample Type: Serum

Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes.
Authors: Lee A, Lam J, Shiu S, Wong Y, Betteridge D, Tan K
PLoS ONE, 2015;10(9):e0137330.
Species: Human
Sample Type: Serum

Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study.
Authors: Heier M, Margeirsdottir H, Gaarder M, Stensaeth K, Brunborg C, Torjesen P, Seljeflot I, Hanssen K, Dahl-Jorgensen K
Cardiovasc Diabetol, 2015;14(1):126.
Species: Human
Sample Type: Serum

Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH.
Authors: Moser B, Megerle A, Bekos C, Janik S, Szerafin T, Birner P, Schiefer A, Mildner M, Lang I, Skoro-Sajer N, Sadushi-Kolici R, Taghavi S, Klepetko W, Ankersmit H
PLoS ONE, 2014;9(9):e106440.
Species: Human
Sample Type: Serum

The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014;14(0):182.
Species: Human
Sample Type: BALF

Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study.
Authors: Zakiyanov O, Kriha V, Vachek J, Zima T, Tesar V, Kalousova M
BMC Nephrol, 2013;14(0):245.
Species: Human
Sample Type: Serum

The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity.
Authors: Brix J, Hollerl F, Kopp H, Schernthaner G, Schernthaner G
Int J Obes (Lond), 2012;36(11):1412-7.
Species: Human
Sample Type: Serum

Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels.
Authors: Campbell D, Somaratne J, Jenkins A, Prior D, Yii M, Kenny J, Newcomb A, Schalkwijk C, Black M, Kelly D
PLoS ONE, 2012;7(11):e49813.
Species: Human
Sample Type: Plasma

Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
Authors: Narvaez-Rivera RM, Rendon A, Salinas-Carmona MC
BMC Infect. Dis., 2012;12(0):15.
Species: Human
Sample Type: Serum

Methodological and Preanalytical Evaluation of a RAGE Immunoassay.
Authors: Wittwer C, Lehner J, Fersching D, Siegele B, Stoetzer OJ, Holdenrieder S
Anticancer Res., 2012;32(5):2075-8.
Species: Human
Sample Type: Serum

Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
Authors: Yamakawa N, Uchida T, Matthay MA, Makita K
Am. J. Physiol. Lung Cell Mol. Physiol., 2011;300(4):L516-25.
Species: Human
Sample Type: pulmonary edema fluid

Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial.
Authors: Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, Demicco DA, Preston GM, Deshmukh H, Tan K, Fuller JH
Diabetes, 2011;60(9):2379-85.
Species: Human
Sample Type: Serum

Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients.
Authors: Jabaudon M, Futier E, Roszyk L
Crit. Care Med., 2011;39(3):480-8.
Species: Human
Sample Type: Plasma

Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study.
Authors: Nin JW, Jorsal A, Ferreira I
Diabetes, 2010;59(8):2027-32.
Species: Human
Sample Type: Plasma

Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes.
Authors: Tam HL, Shiu SW, Wong Y, Chow WS, Betteridge DJ, Tan KC
Atherosclerosis, 2010;209(1):173-7.
Species: Human
Sample Type: Serum

Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.
Authors: Penfold SA, Coughlan MT, Patel SK
Kidney Int., 2010;78(3):287-95.
Species: Human
Sample Type: Serum

Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.
Authors: Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R
Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5779-83.
Species: Human
Sample Type: Plasma

Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome.
Authors: Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(6):L1035-41.
Species: Human
Sample Type: Edema Fluid

Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury.
Authors: Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA
Am. J. Pathol., 2009;175(3):958-75.
Species: Human
Sample Type: Plasma

Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients.
Authors: Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF
Atherosclerosis, 2009;205(2):544-8.
Species: Human
Sample Type: Serum

Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease.
Authors: Mahajan N, Malik N, Bahl A
Atherosclerosis, 2009;207(2):597-602.
Species: Human
Sample Type: Plasma

Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis.
Acta Neurol. Scand., 2009;120(2):119-22.
Species: Human
Sample Type: Serum

Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes.
Authors: Katakami N, Matsuhisa M, Kaneto H, Matsuoka TA, Sakamoto K, Yasuda T, Umayahara Y, Kosugi K, Yamasaki Y
Atherosclerosis, 2009;204(1):288-92.
Species: Human
Sample Type: Serum

Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia.
Authors: Hallstrom L, Berghall E, Frostell C, Sollevi A, Soop AL
Crit. Care Med., 2008;36(11):3043-7.
Species: Human
Sample Type: Plasma

MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.
Authors: Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N
PLoS Med., 2008;5(4):e93.
Species: Human
Sample Type: Serum

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
Authors: Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA,
Thorax, 2008;63(12):1083-9.
Species: Human
Sample Type: Plasma

Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients.
Authors: Gross S, van Ree RM, Oterdoom LH, de Vries AP, van Son WJ, de Jong PE, Navis GJ, Zuurman MW, Bierhaus A, Gans RO, Bakker SJ
Transplantation, 2007;84(5):659-63.
Species: Human
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adhesion Molecules in Angiogenesis
  • APP Cleavage and Amyloid-beta Degradation
  • Blood-brain Barrier Transporters
  • Cell Structure and Signaling Molecules
  • Cytokine and Growth Factor Receptors on VSMC
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • Glucose Homeostasis
  • Immune Regulatory Molecules on Endothelial Cells
  • Inflammatory Mediators
  • Integrins and Associated Molecules
  • Neurodegenerative Disease
  • ROS and Stress Resistance