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Human PlGF Quantikine SixPak (6 Plates) (1 PK)

货号: SPG00 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SPG00
描述The Quantikine Human PlGF Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human PlGF in cell culture supernates, serum, plasma, and urine. The immunoassay kit contains E. coli-expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained using natural human PlGF showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
别名D12S1900; PGF; PGFL; placenta growth factor; placental growth factor; placental growth factor, vascular endothelial growth factor-related protein; PlGF; PlGF-2; PLGFplacental growth factor-like; SHGC-10760;
全称
Placenta Growth Factor
反应种属Human
目标/特异性Natural and recombinant human PlGF
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
5228 (Human); 18654 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma
Authors: D Wu, T Lai, Y Yuan, M Chen, J Xia, W Li, G Pan, B Yuan, Q Lv, Y Li, D Li, B Wu
Sci Rep, 2017;7(0):43017.
Species: Human
Sample Type: Serum

Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
Authors: Ingrid C Weel
PLoS ONE, 2016;11(6):e0157584.
Species: Human
Sample Type: Tissue Homogenates

Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved
Authors: D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens
J Am Heart Assoc, 2016;5(4):.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of placental growth factor in renal cell carcinoma.
Authors: Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, Ong C, Tan S, Matsumoto K, Iwamura M, Teh B
Anticancer Res, 2015;35(1):531-41.
Species: Human
Sample Type: Cell Culture Supernates

Placental growth factor and soluble Fms-like tyrosine kinase 1 in diabetic pregnancy: A possible relation to distal villous immaturity.
Authors: El-Tarhouny S, Almasry S, Elfayomy A, Baghdadi H, Habib F
Histol Histopathol, 2014;29(2):259-72.
Species: Human
Sample Type: Serum

Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis.
Authors: Hou H, Cheng S, Chung K, Kuo M, Yeh C, Chang B, Lu H, Wang H, Yu C
Autophagy, 2014;10(9):1509-21.
Species: Human
Sample Type: Cell Culture Supernates

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Authors: Chaturvedi, Pallavi, Gilkes, Daniele, Wong, Carmen C, Luo, Weibo, Zhang, Huafeng, Wei, Hong, Takano, Naoharu, Schito, Luana, Levchenko, Andre, Semenza, Gregg L
J Clin Invest, 2013;123(1):189-205.
Species: Human
Sample Type: Cell Culture Supernates

Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia.
Authors: Liu, Linda Y, Yang, Ting, Ji, Jun, Wen, Qiaojun, Morgan, Alexande, Jin, Bo, Chen, Gongxing, Lyell, Deirdre, Stevenson, David K, Ling, Xuefeng, Butte, Atul J
BMC Med, 2013;11(0):236.
Species: Human
Sample Type: Serum

Cytokine and angiogenic factors associated with efficacy and toxicity of pazopanib in advanced soft-tissue sarcoma: an EORTC-STBSG study.
Br. J. Cancer, 2012;107(4):639-45.
Species: Human
Sample Type: Serum

Biomarkers for antitumor activity of bevacizumab in gastric cancer models.
Authors: Yamashita-Kashima Y, Fujimoto-Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, Mori K
BMC Cancer, 2012;12(0):37.
Species: Human
Sample Type: Tissue Homogenates

Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
Authors: Loupakis F, Cremolini C, Fioravanti A
Br. J. Cancer, 2011;104(8):1262-9.
Species: Human
Sample Type: Plasma

Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a childrens oncology group study.
Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
Clin. Cancer Res., 2011;17(15):5113-22.
Species: Human
Sample Type: Plasma

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept.
Authors: de Groot JF, Piao Y, Tran H, Gilbert M, Wu HK, Liu J, Bekele BN, Cloughesy T, Mehta M, Robins HI, Lassman A, Deangelis L, Camphausen K, Chen A, Yung W, Prados M, Wen PY, Heymach JV
Clin. Cancer Res., 2011;17(14):4872-4881.
Species: Human
Sample Type: Plasma

Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer.
Authors: Rahbari NN, Schmidt T, Falk CS, Hinz U, Herber M, Bork U, Buchler MW, Weitz J, Koch M
BMC Cancer, 2011;11(0):286.
Species: Human
Sample Type: Serum

Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Authors: Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
Biol. Reprod., 2010;83(1):27-35.
Species: Human
Sample Type: Cell Culture Supernates

Placental growth factor mediates aldosterone-dependent vascular injury in mice.
Authors: Jaffe IZ, Newfell BG, Aronovitz M
J. Clin. Invest., 2010;120(11):3891-900.
Species: Human
Sample Type: Tissue Homogenates

Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.
Authors: Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST
Angiogenesis, 2010;13(4):337-47.
Species: Human
Sample Type: Cell Culture Supernates

Effect of smoking on circulating angiogenic factors in high risk pregnancies.
Authors: Jeyabalan A, Powers RW, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, Caritis S, Roberts JM, Kuller J, Cotroneo M, Kamon T, Mercer B, Ramsey R, Paul R, Rabello Y, McCart D, Mueller E, Goldenberg R, Copper R, Sorokin Y, Norman G, Millinder A, Christmas JT, McCoy S, Elder S, Elder N, Carter B, Pemberton V, Thurnau G, Meier A, Minton V, Meis P, Swain M, Moawad AH, Jones P, Iams JD, Meadows S, Brenner S, Collins B, Newman RB, Carter SG, Romero R, Sabo V, Thom E, Bain RP, MacPherson C, Johnson D, Fischer ML, McNellis D, Spong C, Catz C, Yaffe S
PLoS ONE, 2010;5(10):e13270.
Species: Human
Sample Type: Serum

Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies.
Authors: Powers RW, Jeyabalan A, Clifton RG
PLoS ONE, 2010;5(10):e13263.
Species: Human
Sample Type: Serum

Placenta growth factor in sickle cell disease: association with hemolysis and inflammation.
Authors: Brittain JE, Hulkower B, Jones SK, Strayhorn D, De Castro L, Telen MJ, Orringer EP, Hinderliter A, Ataga KI
Blood, 2010;115(10):2014-20.
Species: Human
Sample Type: Plasma

An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia.
Authors: Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl MG, Pape J, Dudenhausen JW, Denk B, Stepan H
Am. J. Obstet. Gynecol., 2010;202(2):161.e1-161.e1.
Species: Human
Sample Type: Serum

Placental Growth Factor: A Promising Diagnostic Biomarker for Tubal Ectopic Pregnancy.
Authors: Horne AW, Shaw JL
J. Clin. Endocrinol. Metab., 2010;0(0):.
Species: Human
Sample Type: Serum

Potential role for plasma placental growth factor in predicting coronary heart disease risk in women.
Authors: Cassidy A, Chiuve SE, Manson JE, Rexrode KM, Girman CJ, Rimm EB
Arterioscler. Thromb. Vasc. Biol., 2009;29(1):134-9.
Species: Human
Sample Type: Plasma

Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma.
Authors: Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ
J. Clin. Oncol., 2008;26(22):3743-8.
Species: Human
Sample Type: Plasma

Endometrial NK cells are special immature cells that await pregnancy.
Authors: Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
J. Immunol., 2008;181(3):1869-76.
Species: Human
Sample Type: Cell Culture Supernates

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates

Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia.
Authors: Jeyabalan A, Powers RW, Durica AR, Harger GF, Roberts JM, Ness RB
Am. J. Hypertens., 2008;21(8):943-7.
Species: Human
Sample Type: Plasma

Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
J. Am. Coll. Cardiol., 2008;52(5):387-93.
Species: Human
Sample Type: Plasma

Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.
Authors: Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E
Fertil. Steril., 2008;89(4):922-6.
Species: Human
Sample Type: Serum

Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.
Authors: Apple FS, Pearce LA, Chung A, Ler R, Murakami MM
Clin. Chem., 2007;53(5):874-81.
Species: Human
Sample Type: Plasma

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
Authors: Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D
Clin. Sci., 2007;112(1):51-7.
Species: Human
Sample Type: Serum

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
J. Am. Coll. Cardiol., 2007;49(24):2341-9.
Species: Human
Sample Type: Bone Marrow Plasma

Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction.
Authors: Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, Asai O, Onoue K, Okayama S, Somekawa S, Kida Y, Takeda Y, Nakatani K, Takaoka M, Kawata H, Horii M, Nakajima T, Doi N, Saito Y
J. Am. Coll. Cardiol., 2006;47(8):1559-67.
Species: Human
Sample Type: Plasma

Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
Glia, 2006;53(8):845-57.
Species: Human
Sample Type: Cell Culture Supernates

Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
Authors: Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA
N. Engl. J. Med., 2006;355(10):992-1005.
Species: Human
Sample Type: Serum

Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.
Authors: Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T
Am. J. Pathol., 2006;169(4):1167-82.
Species: Human
Sample Type: Tissue Homogenates

Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis.
Authors: Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y
Am. J. Obstet. Gynecol., 2006;194(2):551-6.
Species: Human
Sample Type: Serum

Urinary placental growth factor and risk of preeclampsia.
Authors: Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
JAMA, 2005;293(1):77-85.
Species: Human
Sample Type: Urine

Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.
Authors: Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA
Am. J. Obstet. Gynecol., 2005;192(3):734-41.
Species: Human
Sample Type: Urine

Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals.
Authors: Briguori C, Testa U, Colombo A, Petrucci E, Condorelli G, Airoldi F, Peschle C, Condorelli G
Am. J. Cardiol., 2005;97(4):472-6.
Species: Human
Sample Type: Serum

Circulating angiogenic factors and the risk of preeclampsia.
Authors: Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA
N. Engl. J. Med., 2004;350(7):672-83.
Species: Human
Sample Type: Serum

A potential pro-angiogenic cell therapy with human placenta-derived mesenchymal cells.
Authors: Nishishita T, Ouchi K, Zhang X, Inoue M, Inazawa T, Yoshiura K, Kuwabara K, Nakaoka T, Watanabe N, Igura K, Takahashi TA, Yamashita N
Biochem. Biophys. Res. Commun., 2004;325(1):24-31.
Species: Human
Sample Type: Cell Lysates

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
Authors: Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA
J. Clin. Invest., 2003;111(5):649-58.
Species: Human
Sample Type: Serum

Overexpression of placenta growth factor contributes to the pathogenesis of pulmonary emphysema.
Authors: Tsao PN, Su YN, Li H, Huang PH, Chien CT, Lai YL, Lee CN, Chen CA, Cheng WF, Wei SC, Yu CJ, Hsieh FJ, Hsu SM
Am. J. Respir. Crit. Care Med., 2003;169(4):505-11.
Species: Human
Sample Type: Serum

A longitudinal study of biochemical variables in women at risk of preeclampsia.
Authors: Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L
Am. J. Obstet. Gynecol., 2002;187(1):127-36.

Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
Authors: Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ
Am. J. Pathol., 2002;160(4):1405-23.
Species: Human
Sample Type: Cell Culture Supernates

A critical role of placental growth factor in the induction of inflammation and edema formation.
Authors: Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M
Blood, 2002;101(2):560-7.
Species: Human
Sample Type: Cell Lysates

生物活性Cross-reactivity observed with 1 or more available related molecules.Cross-species reactivity not tested.
背景PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.
运输条件Blue Ice
存放说明4℃
参考文献
  • Epithelial Cell Markers and Intracellular Molecules
  • HIF Transcription Factors
  • Preeclampsia
  • Surface Ectodermal Cells
  • VEGF Family
  • VEGF Family Ligands