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Human CD40 Ligand/TNFSF5 Quantikine SixPak (6 Plates) (1 PK)

货号: SCDL40 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SCDL40
描述The Quantikine Human CD40 Ligand Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CD40 Ligand in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human CD40 Ligand and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CD40 Ligand showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CD40 Ligand.
别名CD154 antigen; CD154; CD40 antigen ligand; CD40 Ligand; CD40-L; CD40LG; CD40LIGM; gp39; hCD40L; HIGM1; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TNFSF5IMD3; TRAP; TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome); tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5;
反应种属Human
目标/特异性Natural and recombinant human CD40 Ligand
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
959 (Human); 21947 (Mouse); 84349 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis
Sci Rep, 2016;6(0):36862.
Species: Human
Sample Type: Plasma

Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma
Onco Targets Ther, 2016;9(0):4681-6.
Species: Human
Sample Type: Serum

Involvement of Rac in thromboxane A2induced human platelet activation: regulation of sCD40 ligand release and PDGFAB secretion.
Authors: Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S
Mol Med Rep, 2014;10(1):107-12.
Species: Human
Sample Type: Plasma

Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling.
Authors: Fuentes E, Pereira J, Mezzano D, Alarcon M, Caballero J, Palomo I
PLoS ONE, 2014;9(11):e112741.
Species: Human
Sample Type: Cell Culture Supernates

Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo.
Authors: Silliman C, Kelher M, Khan S, LaSarre M, West F, Land K, Mish B, Ceriano L, Sowemimo-Coker S
Blood, 2014;123(22):3488-95.
Species: Human
Sample Type: Serum

Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L.
Authors: Fuentes E, Alarcon M, Astudillo L, Valenzuela C, Gutierrez M, Palomo I
Molecules, 2013;18(7):8120-35.
Species: Human
Sample Type: Platelet Concentrate

Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity.
Authors: Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR
Crit. Care Med., 2012;40(6):1844-50.
Species: Human
Sample Type: Plasma

Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura.
J. Thromb. Haemost., 2012;10(8):1616-23.
Species: Human
Sample Type: Serum

Prospective study of circulating soluble CD40 ligand concentrations and the incidence of cardiovascular disease in a nested prospective case-control study of older men and women.
Authors: Jefferis BJ, Whincup PH, Welsh P, Wannamethee SG, Rumley A, Lawlor DA, Ebrahim S, Lowe GD
J. Thromb. Haemost., 2011;9(8):1452-9.
Species: Human
Sample Type: Serum

High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality.
Authors: Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, Ostrowski SR
J. Thromb. Haemost., 2011;10(2):207-16.
Species: Human
Sample Type: Plasma

Pre-operative platelet-bound CD40 ligand is probably associated with peri-operative cardiac events in hip and knee arthroplasty.
Authors: Ray MJ, Calabro LJ, Sirisena T, Crawford SA, Crawford RW, Walters DL
Eur. J. Clin. Invest., 2010;40(6):497-503.
Species: Human
Sample Type: Plasma

Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.
Authors: Kawut SM, Barr RG, Johnson WC
Biomarkers, 2010;15(8):731-8.
Species: Human
Sample Type: Plasma

Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden.
Authors: Arellano-Rodrigo E, Alvarez-Larran A, Reverter JC, Colomer D, Villamor N, Bellosillo B, Cervantes F
Am. J. Hematol., 2009;84(2):102-8.
Species: Human
Sample Type: Plasma

A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.
Authors: Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP
J. Nutr., 2009;139(6):1143-9.
Species: Human
Sample Type: Plasma

Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
Diabetes Care, 2009;32(3):486-92.
Species: Human
Sample Type: Plasma

Soluble CD40 ligand as a biomarker for storage-related preanalytic variations of human serum.
Authors: Lengelle J, Panopoulos E, Betsou F
Cytokine, 2008;44(2):275-82.
Species: Human
Sample Type: Serum

Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men.
Authors: Damsgaard CT, Frokiaer H, Andersen AD, Lauritzen L
J. Nutr., 2008;138(6):1061-6.
Species: Human
Sample Type: Serum

Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome.
Authors: Undas A, Wiek I, Stepien E, Zmudka K, Tracz W
Diabetes Care, 2008;31(8):1590-5.
Species: Human
Sample Type: Plasma

Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke.
Authors: Dai DF, Thajeb P, Tu CF, Chiang FT, Chen CH, Yang RB, Chen JJ
J. Am. Coll. Cardiol., 2008;51(22):2173-80.
Species: Human
Sample Type: Plasma

Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
Authors: Beres BJ, Toth-Zsamboki E, Vargova K, László A, Masszi T, Kerecsen G, Preda I, Kiss RG
Thromb. Haemost., 2008;100(5):829-38.
Species: Human
Sample Type: Plasma

Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus--an effect probably mediated by direct platelet PPARgamma activation.
Authors: Khanolkar MP, Morris RH, Thomas AW, Bolusani H, Roberts AW, Geen J, Jackson SK, Evans LM
Atherosclerosis, 2007;197(2):718-24.
Species: Human
Sample Type: Serum

Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes.
Authors: Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W
Eur. Heart J., 2007;28(8):941-8.
Species: Human
Sample Type: Serum

Relationship of soluble CD40 ligand to vascular endothelial growth factor, angiopoietins, and tissue factor in atrial fibrillation: a link among platelet activation, angiogenesis, and thrombosis?
Authors: Choudhury A, Freestone B, Patel J, Lip GY
Chest, 2007;132(6):1913-9.
Species: Human
Sample Type: Plasma

Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.
Authors: Apple FS, Pearce LA, Chung A, Ler R, Murakami MM
Clin. Chem., 2007;53(5):874-81.
Species: Human
Sample Type: Plasma

No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.
Authors: Solheim S, Pettersen AA, Arnesen H, Seljeflot I
Thromb. Haemost., 2006;96(5):660-4.
Species: Human
Sample Type: Plasma

Humoral and cellular factors responsible for coronary collateral formation.
Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
Am. J. Cardiol., 2006;98(9):1194-7.
Species: Human
Sample Type: Plasma

Effects of simvastatin on angiogenic growth factors released at the site of microvascular injury.
Authors: Undas A, Celinska-Lowenhoff M, Stepien E, Nizankowski R, Tracz W, Szczeklik A
Thromb. Haemost., 2006;95(6):1045-7.
Species: Human
Sample Type: Plasma

Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients.
Authors: Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Kim JA, Lee Y, Shin EK
Diabetes Care, 2006;29(2):195-201.

Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus.
Authors: Chu CS, Lee KT, Lee MY, Su HM, Voon WC, Sheu SH, Lai WT
Am. J. Cardiol., 2006;97(5):646-50.
Species: Human
Sample Type: Serum

Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome.
Authors: Wang TD, Chen WJ, Cheng WC, Lin JW, Chen MF, Lee YT
Am. J. Cardiol., 2006;98(8):1057-62.
Species: Human
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CD40 Ligand, also known as TNFSF5, CD154, TRAP, and gp39, is a trimeric protein that is expressed in transmembrane and soluble forms. It is expressed by many immune cell types as well as by endothelial and smooth muscle cells of the vasculature. It binds to CD40 on antigen presenting cells, platelets, and endothelial and epithelial cells, leading to enhanced B cell activation and T cell dependent humoral immune responses. CD40 Ligand dysregulation contributes to immune pathology in AIDS, atherosclerosis, atherothrombosis, and restenosis.
运输条件Blue Ice
存放说明4℃
参考文献
  • Co-stimulatory and Co-inhibitory Molecules
  • Co-stimulatory Molecules Associated with Tfh Cells
  • gamma delta T Cells
  • Immune Regulatory Molecules on Endothelial Cells
  • Platelets
  • Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
  • Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
  • Regulation of T Cell Co-stimulation by TNF Superfamily Members
  • Regulatory T Cells (Tregs)
  • TNF Superfamily
  • TNF Superfamily Ligands